Evidence map›Paper›PMID 25453460›Full record

ReviewThe Lancet. Neurology2014

Clinical symptoms, diagnosis, and treatment of neurocysticercosis.

Hector H Garcia, Theodore E Nash, Oscar H Del Brutto

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in The Lancet. Neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 275 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
275citing papers in PubMed, 5 pooled it
22.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04706819 unknown statusnot on this mapstarted 2021, after this paper: background citation

Clinical, Laboratory and Imaging Features, Treatment Trends and Long Term Outcomes in Patients With Parenchymal and Extraparenchymal Neurocysticercosis-A Registry Based Study

Typeobservational_patient_registrySponsorAll India Institute of Medical SciencesRan2021 to 2025Enrolled1,000ConditionsNeurocysticercosis, Tropical Disease, Tenia Solium Infection
NCT06376396 phase4not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Assessment of Combined Antiparasitic Drugs Praziquantel and Albendazole Versus Albendazole Alone in the Treatment of Active Parenchymal Neurocysticercosis in Tanzania and Zambia

TypeinterventionalSponsorR-Evolution Worldwide S.r.l. Impresa SocialeRan2024 to 2026Enrolled300ConditionsNeurocysticercosisArmsalbendazole and praziquantel, Albendazole
3 · Its place in the literature

Who cites it

275 citing papers in PubMed, 5 syntheses or guidelines pooled it, 570 citations in OpenAlex.

  1. Movement Disorders in Neurocysticercosis: A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025
    Pooled it
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  3. Neurocysticercosis: challenges in pediatric neurosurgery practice.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
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215 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Hector H GarciaCysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Peru; Centre for Global Health-Tumbes and Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru. Electronic address: hgarcia@jhsph.edu.
Theodore E NashLaboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Oscar H Del BruttoSchool of Medicine, Universidad Espíritu Santo-Ecuador, Guayaquil, Ecuador; Department of Neurological Sciences, Hospital-Clínica Kennedy, Guayaquil, Ecuador.
National Institute of Allergy and Infectious Diseases · USUniversidad de Especialidades Espíritu Santo · ECUniversidad Peruana Cayetano Heredia · PE

Funding

Studies of neurocysticercosis and animal cestode infectionsZIAAI000846 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NASH, THEODORE · 2009 to 2020
$9.5M
Studies of neurocysticercosis and animal cestode infectionsZ01AI000846 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI NASH, THEODORE · 1999 to 2008
$831k
Intramural NIH HHS Z01 AI000846Wellcome Trust 091077
6 · The paper itself

Abstract

The infection of the nervous system by the cystic larvae of Taenia solium (neurocysticercosis) is a frequent cause of seizure disorders. Neurocysticercosis is endemic or presumed to be endemic in many low-income countries. The lifecycle of the worm and the clinical manifestations of neurocysticercosis are well established, and CT and MRI have substantially improved knowledge of the disease course. Improvements in immunodiagnosis have further advanced comprehension of the pathophysiology of this disease. This knowledge has led to individualised treatment approaches that account for the involvement of parenchymal or extraparenchymal spaces, the number and form of parasites, and the extent of degeneration and associated inflammation. Clinical investigations are focused on development of effective treatments and reduction of side-effects induced by treatment, such as seizures, hydrocephalus, infarcts, and neuroinjury.

Indexed as

Taenia soliumAnimalsHumansMagnetic Resonance ImagingNeurocysticercosisSeizuresSwineTomography, X-Ray ComputedTreatment Outcome

Identifiers

PMID25453460
PMCPMC6108081
OpenAlexW2101023609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.