Evidence map›Paper›PMID 25452840›Full record

ReviewUnited European gastroenterology journal2014

Colonic motility in ulcerative colitis.

Gabrio Bassotti, Elisabetta Antonelli, Vincenzo Villanacci, Monia Baldoni, Maria Pina Dore

Open access · bronzeAbstract readReview
In one paragraph

Review in United European gastroenterology journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Review
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  9. Review
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  14. Article
  15. Esculentoside A Alleviates Intestinal Dysmotility in Ulcerative Colitis by Regulating HEvidence-based complementary and alternative medicine : eCAM · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Ulcerative colitis and the aging-related development of colonic diverticula.International journal of colorectal disease · 2018
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Gabrio BassottiGastroenterology Section, Department of Medicine, University of Perugia, Perugia, Italy.
Elisabetta AntonelliGastroenterology Unit, Perugia General Hospital, Perugia, Italy.
Vincenzo VillanacciPathology Section, Department of Molecular and Translational Medicine, Spedali Civili and University of Brescia, Italy.
Monia BaldoniGastroenterology Section, Department of Medicine, University of Perugia, Perugia, Italy.
Maria Pina DoreDepartment of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy ; Baylor College of Medicine, Houston, Texas, USA.
University of Perugia · ITUniversity of Brescia · ITUniversity of Sassari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammatory conditions affecting the gut may cause motility disturbances, and ulcerative colitis - one of the main disorders among the inflammatory bowel diseases - may display abnormal colonic motility.

aimTo review the abnormalities of the large bowel in ulcerative colitis, by considering the motility, laboratory (in vitro) and pathological studies dealing with this topic.

methodsA comprehensive online search of Medline and the Science Citation Index was carried out.

resultsPatients with ulcerative colitis frequently display colonic motor abnormalities, including lack of contractility, an increase of propulsive contractile waves, an excessive production of nitric oxide, vasoactive intestinal polypeptide nerves, interleukin 1 beta, neurotensin, tachykinins levels and the weaker action of substance P, likely related to a neuromuscular dysfunction due to the inflammatory process.

conclusionsA better understanding of the pathophysiological grounds of altered colonic motility in ulcerative colitis may lead to a more in-depth knowledge of the accompanying symptoms and to better and more targeted therapeutic approaches.

Indexed as

Colonenteric nervous systeminflammationmanometrymotilitymyenteric plexusulcerative colitis

Identifiers

PMID25452840
PMCPMC4245297
OpenAlexW2114880692

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.