ArticleExperimental and therapeutic medicine2015
A retrospective analysis of the clinicopathological characteristics of large cell carcinoma of the lung.
Article in Experimental and therapeutic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Is CK7 a Prognostic Marker in Pulmonary LCNEC? Evidence from a Limited Cohort Study.Journal of personalized medicine · 2025Article
- Pre-procedureDiagnostic and interventional radiology (Ankara, Turkey) · 2024Article
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- Effect of Chemotherapy in Stage II-IV Large-Cell Lung Carcinoma and Construction of Its Predictive Nomograms: A SEER Analysis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2023Article
- Pulmonary Large Cell Neuroendocrine Carcinoma.Pathology oncology research : POR · 2022Review
- A nomogram prognostic model for large cell lung cancer: analysis from the Surveillance, Epidemiology and End Results Database.Translational lung cancer research · 2021Article
- Treatment of Advanced-Stage Large Cell Neuroendocrine Cancer (LCNEC) of the Lung: A Tale of Two Diseases.Frontiers in oncology · 2021Review
- The role of radiotherapy in pulmonary large cell neuroendocrine carcinoma: propensity score matching analysis.Journal of radiation research · 2020Article
- Secretagogin, a marker for neuroendocrine cells, is more sensitive and specific in large cell neuroendocrine carcinoma compared with the markers CD56, CgA, Syn and Napsin A.Oncology letters · 2020Article
- Clinicopathological characteristics withTranslational cancer research · 2019Article
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- Primary pulmonary lymphoepithelioma-like carcinoma in non-endemic region: A case report and literature review.Medicine · 2018Review
- PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.Experimental and therapeutic medicine · 2017Article
- Clinicopathological features and prognosis of primary pulmonary lymphoepithelioma-like carcinoma.Journal of thoracic disease · 2016Article
- Treatment of lung large cell neuroendocrine carcinoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to analyze and summarize the clinicopathological characteristics of large-cell lung carcinoma (LCLC) of the lung, in order to improve the definite diagnosis rate of LCLC. Clinicopathological data of 174 patients with LCLC, confirmed pathologically, were retrospectively reviewed. The 174 cases of LCLC accounted for 5.7% of the total lung cancer cases during the corresponding time period at the Affiliated Cancer Hospital of Tianjin Medical University (Tianjin, China), among which there were 131 males and 43 females with an average age of 61.4 years. The postoperative pathological diagnosis of the 174 cases showed 80 cases of classic LCLC, 64 cases of large cell neuroendocrine carcinoma (LCNEC), six cases of combined LCNEC, 19 cases of basaloid carcinoma, three cases of clear cell carcinoma and two cases of lymphoepithelioma-like carcinoma. Of the total 174 LCLC cases, 96 patients exhibited lymph node metastasis. LCLC is a highly aggressive malignancy with a high tendency of invasion and metastasis, although the incidence rate is low. A definite diagnosis of LCLC primarily relies on the pathological diagnosis. Each subtype of LCLC has its own pathomorphological and immunohistochemical characteristics.
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