ArticleExperimental and therapeutic medicine2015
Extracts of black bean peel and pomegranate peel ameliorate oxidative stress-induced hyperglycemia in mice.
Article in Experimental and therapeutic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Genetic variation and historical breeding patterns in common bean (Phaseolus vulgaris L.) affect fermentation patterns by the human gut microbiome.Communications biology · 2025Article
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- The Impact ofAntioxidants (Basel, Switzerland) · 2023Review
- Punicalagin protects against the development of pancreatic injury and insulitis in rats with induced T1DM by reducing inflammation and oxidative stress.Molecular and cellular biochemistry · 2022Article
- Standardised pomegranate peel extract lavage prevents postoperative peritoneal adhesion by regulating TGF-β and VEGF levels.Inflammopharmacology · 2021Article
- Chloroplast Genome Sequencing, Comparative Analysis, and Discovery of Unique Cytoplasmic Variants in Pomegranate (Frontiers in genetics · 2021Article
- Ellagic Acid as a Tool to Limit the Diabetes Burden: Updated Evidence.Antioxidants (Basel, Switzerland) · 2020Review
- Anthocyanins and Human Health-A Focus on Oxidative Stress, Inflammation and Disease.Antioxidants (Basel, Switzerland) · 2020Review
- The Complete Chloroplast Genomes ofInternational journal of molecular sciences · 2019Article
- Effects of PomegranateAdvanced pharmaceutical bulletin · 2017Article
- Gamma Amino Butyric Acid Attenuates Brain Oxidative Damage Associated with Insulin Alteration in Streptozotocin-Treated Rats.Indian journal of clinical biochemistry : IJCB · 2017Article
- Pomegranate juice causes a partial improvement through lowering oxidative stress for erectile dysfunction in streptozotocin-diabetic rat.International journal of impotence research · 2016Article
- Genome-wide identification of microRNAs in pomegranate (Punica granatum L.) by high-throughput sequencing.BMC plant biology · 2016Article
- Genetic diversity and association mapping of bacterial blight and other horticulturally important traits with microsatellite markers in pomegranate from India.Molecular genetics and genomics : MGG · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress has a central role in the progression of diabetes mellitus (DM), which can directly result in the injury of islet β cells and consequent hyperglycemia. The aim of the present study was to evaluate the possible protective effects of black bean peel extract (BBPE), pomegranate peel extract (PPE) and a combination of the two (PPE + BBPE) on streptozotocin-induced DM mice. Oxidative stress was assessed by the levels of total antioxidative capability and glutathione in the serum. Fasting blood glucose and insulin levels, as well as the pancreas weight index and the histological changes in the pancreas, were also determined. The results showed that, after fours weeks of treatment with PPE, BBPE or PPE + BBPE, DM mice showed, to different degrees, a decrease in blood glucose, increases in insulin secretion and the pancreas weight index, and an increase in antioxidative activity. These changes were particularly evident in the DM mice subjected to the combined intervention strategy of PPE + BBPE. The histological findings indicated that the injury to the pancreatic islets in DM mice was also ameliorated following treatment. In conclusion, PPE and BBPE, particularly the combination of the two, have the ability to ameliorate hyperglycemia by inhibiting oxidative stress-induced pancreatic damage; this finding may be useful in the prevention and treatment of DM.
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