ReviewFrontiers in microbiology2014
Novel approaches to identify protective malaria vaccine candidates.
Review in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Identification of novelFrontiers in cellular and infection microbiology · 2023Article
- The Delay in the Licensing of Protozoal Vaccines: A Comparative History.Frontiers in immunology · 2020Review
- Immunomic Identification of Malaria Antigens Associated With Protection in Mice.Molecular & cellular proteomics : MCP · 2019Article
- A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum.Nature communications · 2018Article
- Identification of target proteins of clinical immunity to Plasmodium falciparum in a region of low malaria transmission.Parasitology international · 2018Article
- Article
- Isolation and Characterization of Vaccine Candidate Genes IncludingThe Korean journal of parasitology · 2017Article
- Breadth of humoral response and antigenic targets of sporozoite-inhibitory antibodies associated with sterile protection induced by controlled human malaria infection.Cellular microbiology · 2016Article
- IL-22 dampens the T cell response in experimental malaria.Scientific reports · 2016Article
- Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection.Frontiers in immunology · 2016Review
- Immunization with the MAEBL M2 Domain Protects against Lethal Plasmodium yoelii Infection.Infection and immunity · 2015Article
- The PfAlba1 RNA-binding protein is an important regulator of translational timing in Plasmodium falciparum blood stages.Genome biology · 2015Article
- Immunogenicity of infectious pathogens and vaccine antigens.BMC immunology · 2015Review
- Editorial: Breaking the cycle: attacking the malaria parasite in the liver.Frontiers in microbiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Efforts to develop vaccines against malaria have been the focus of substantial research activities for decades. Several categories of candidate vaccines are currently being developed for protection against malaria, based on antigens corresponding to the pre-erythrocytic, blood stage, or sexual stages of the parasite. Long lasting sterile protection from Plasmodium falciparum sporozoite challenge has been observed in human following vaccination with whole parasite formulations, clearly demonstrating that a protective immune response targeting predominantly the pre-erythrocytic stages can develop against malaria. However, most of vaccine candidates currently being investigated, which are mostly subunits vaccines, have not been able to induce substantial (>50%) protection thus far. This is due to the fact that the antigens responsible for protection against the different parasite stages are still yet to be known and relevant correlates of protection have remained elusive. For a vaccine to be developed in a timely manner, novel approaches are required. In this article, we review the novel approaches that have been developed to identify the antigens for the development of an effective malaria vaccine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.