ReviewFrontiers in cellular neuroscience2014
Molecules and mechanisms that regulate multipolar migration in the intermediate zone.
Review in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 96 citations in OpenAlex.
- Structurally exclusive Teneurin complexes orchestrate divergent programs in early cortical development.Nature communications · 2026Article
- Architects of the Developing Brain: Cytoskeleton-Organizing Molecules in Neurodevelopmental Disorders.Cells · 2026Review
- Spatiotemporal coordination of Slit-Robo repulsion and neurturin-Gfrα attraction guides multipolar migration during retinal lamination.Cell reports · 2026Article
- Sevoflurane Inhibits the Proliferation of Neural Precursor Cells and Neural Migration of Mice by Inducing Iron Metabolism Disorders.CNS neuroscience & therapeutics · 2025Article
- Laminar organization of the anterior olfactory nucleus-the interplay between neurogenesis timing and neuroblast migration.Frontiers in neuroscience · 2025Article
- Morphogenetic theory of mental and cognitive disorders: the role of neurotrophic and guidance molecules.Frontiers in molecular neuroscience · 2024Review
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- Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar-Bipolar Transition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Molecular mechanisms of corpus callosum development: a four-step journey.Frontiers in neuroanatomy · 2023Review
- Tbr1 Misexpression Alters Neuronal Development in the Cerebral Cortex.Molecular neurobiology · 2022Article
- Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina.eLife · 2022Article
- Article
- Transcription factor 4 controls positioning of cortical projection neurons through regulation of cell adhesion.Molecular psychiatry · 2021Article
- STK25 and MST3 Have Overlapping Roles to Regulate Rho GTPases during Cortical Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Inheritance and flexibility of cell polarity: a clue for understanding human brain development and evolution.Development (Cambridge, England) · 2021Article
- SRPS associated protein WDR60 regulates the multipolar-to-bipolar transition of migrating neurons during cortical development.Cell death & disease · 2021Article
- Evolution of the Neocortex Through RNA-Binding Proteins and Post-transcriptional Regulation.Frontiers in neuroscience · 2021Review
- Article
- Loss of PHF6 leads to aberrant development of human neuron-like cells.Scientific reports · 2020Article
- Reelin-Nrp1 Interaction Regulates Neocortical Dendrite Development in a Context-Specific Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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1 author at 1 institution in 1 country.
Funding
Abstract
Most neurons migrate with an elongated, "bipolar" morphology, extending a long leading process that explores the environment. However, when immature projection neurons enter the intermediate zone (IZ) of the neocortex they become "multipolar". Multipolar cells extend and retract cytoplasmic processes in different directions and move erratically-sideways, up and down. Multipolar cells extend axons while they are in the lower half of the IZ. Remarkably, the cells then resume radial migration: they reorient their centrosome and Golgi apparatus towards the pia, transform back to bipolar morphology, and commence locomotion along radial glia (RG) fibers. This reorientation implies the existence of directional signals in the IZ that are ignored during the multipolar stage but sensed after axonogenesis. In vivo genetic manipulation has implicated a variety of candidate directional signals, cell surface receptors, and signaling pathways, that may be involved in polarizing multipolar cells and stabilizing a pia-directed leading process for radial migration. Other signals are implicated in starting multipolar migration and triggering axon outgrowth. Here we review the molecules and mechanisms that regulate multipolar migration, and also discuss how multipolar migration affects the orderly arrangement of neurons in layers and columns in the developing neocortex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.