ArticleMicrobiology insights2014
Evaluative profiling of arsenic sensing and regulatory systems in the human microbiome project genomes.
Article in Microbiology insights, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Phosphate Uptake and Its Relation to Arsenic Toxicity in Lactobacilli.International journal of molecular sciences · 2024Article
- Ecological Trait-Based Digital Categorization of Microbial Genomes for Denitrification Potential.Microorganisms · 2024Article
- Strain-level profiling of viable microbial community by selective single-cell genome sequencing.Scientific reports · 2022Article
- The gut microbiome and arsenic-induced disease-iAs metabolism in mice.Current environmental health reports · 2021Review
- Arsenic Accumulation of Realgar Altered by Disruption of Gut Microbiota in Mice.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- High-Fat Diet Affects Heavy Metal Accumulation and Toxicity to Mice Liver and Kidney Probably via Gut Microbiota.Frontiers in microbiology · 2020Article
- Gut microbiome disruption altered the biotransformation and liver toxicity of arsenic in mice.Archives of toxicology · 2019Article
- The gut microbiome is required for full protection against acute arsenic toxicity in mouse models.Nature communications · 2018Article
- Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- The microbiome in urogenital schistosomiasis and induced bladder pathologies.PLoS neglected tropical diseases · 2017Article
- Genomic Evidence for Bacterial Determinants Influencing Obesity Development.International journal of environmental research and public health · 2017Article
- H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa.Genome research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
The influence of environmental chemicals including arsenic, a type 1 carcinogen, on the composition and function of the human-associated microbiota is of significance in human health and disease. We have developed a suite of bioinformatics and visual analytics methods to evaluate the availability (presence or absence) and abundance of functional annotations in a microbial genome for seven Pfam protein families: As(III)-responsive transcriptional repressor (ArsR), anion-transporting ATPase (ArsA), arsenical pump membrane protein (ArsB), arsenate reductase (ArsC), arsenical resistance operon transacting repressor (ArsD), water/glycerol transport protein (aquaporins), and universal stress protein (USP). These genes encode function for sensing and/or regulating arsenic content in the bacterial cell. The evaluative profiling strategy was applied to 3,274 genomes from which 62 genomes from 18 genera were identified to contain genes for the seven protein families. Our list included 12 genomes in the Human Microbiome Project (HMP) from the following genera: Citrobacter, Escherichia, Lactobacillus, Providencia, Rhodococcus, and Staphylococcus. Gene neighborhood analysis of the arsenic resistance operon in the genome of Bacteroides thetaiotaomicron VPI-5482, a human gut symbiont, revealed the adjacent arrangement of genes for arsenite binding/transfer (ArsD) and cytochrome c biosynthesis (DsbD_2). Visual analytics facilitated evaluation of protein annotations in 367 genomes in the phylum Bacteroidetes identified multiple genomes in which genes for ArsD and DsbD_2 were adjacently arranged. Cytochrome c, produced by a posttranslational process, consists of heme-containing proteins important for cellular energy production and signaling. Further research is desired to elucidate arsenic resistance and arsenic-mediated cellular energy production in the Bacteroidetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.