ArticleThe Journal of experimental biology2015
Prioritization of skeletal muscle growth for emergence from hibernation.
Article in The Journal of experimental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Incorporation of microbially salvaged urea-nitrogen into anabolic amino acids during hibernation in arctic ground squirrels.Communications biology · 2026Article
- Host-microbiome mutualism drives urea carbon salvage and acetogenesis during hibernation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Incorporation of microbially salvaged urea-nitrogen into anabolic amino acids during hibernation in arctic ground squirrels.bioRxiv : the preprint server for biology · 2025Article
- Skeletal muscle preservation in arctic ground squirrels during hibernation season.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2025Article
- Microbial urea-nitrogen recycling in arctic ground squirrels: the effect of ambient temperature of hibernation.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Article
- Proteomic Identification of Seasonally Expressed Proteins Contributing to Heart Function and the Avoidance of Skeletal Muscle Disuse Atrophy in a Hibernating Mammal.Journal of proteome research · 2024Article
- Energy and time optimization during exit from torpor in vertebrate endotherms.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Nitrogen recycling via gut symbionts increases in ground squirrels over the hibernation season.Science (New York, N.Y.) · 2022Article
- What programs the size of animal cells?Frontiers in cell and developmental biology · 2022Review
- Development of metabolic inflammation during pre-hibernation fattening in 13-lined ground squirrels (Ictidomys tridecemlineatus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Article
- Body Protein Sparing in Hibernators: A Source for Biomedical Innovation.Frontiers in physiology · 2021Review
- Nitrogen recycling buffers against ammonia toxicity from skeletal muscle breakdown in hibernating arctic ground squirrels.Nature metabolism · 2020Article
- Transcriptional changes in muscle of hibernating arctic ground squirrels (Urocitellus parryii): implications for attenuation of disuse muscle atrophy.Scientific reports · 2020Article
- Autophagy and Akt-mTOR signaling display periodic oscillations during torpor-arousal cycles in oxidative skeletal muscle of Daurian ground squirrels (Spermophilus dauricus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- A Temporal Examination of Cytoplasmic CaFrontiers in physiology · 2020Article
- Waking the sleeping dragon: gene expression profiling reveals adaptive strategies of the hibernating reptile Pogona vitticeps.BMC genomics · 2019Article
- Overwintering adaptations and extreme freeze tolerance in a subarctic population of the wood frog, Rana sylvatica.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2019Review
- Comparative tissue transcriptomics highlights dynamic differences among tissues but conserved metabolic transcript prioritization in preparation for arousal from torpor.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Properties of skeletal muscle in the teleost Sternopygus macrurus are unaffected by short-term electrical inactivity.Physiological genomics · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Mammalian hibernators provide an extreme example of naturally occurring challenges to muscle homeostasis. The annual hibernation cycle is characterized by shifts between summer euthermy with tissue anabolism and accumulation of body fat reserves, and winter heterothermy with fasting and tissue catabolism. The circannual patterns of skeletal muscle remodelling must accommodate extended inactivity during winter torpor, the motor requirements of transient winter active periods, and sustained activity following spring emergence. Muscle volume in thirteen-lined ground squirrels (Ictidomys tridecemlineatus) calculated from MRI upper hindlimb images (n=6 squirrels, n=10 serial scans) declined from hibernation onset, reaching a nadir in early February. Paradoxically, mean muscle volume rose sharply after February despite ongoing hibernation, and continued total body mass decline until April. Correspondingly, the ratio of muscle volume to body mass was steady during winter atrophy (October-February) but increased (+70%) from February to May, which significantly outpaced changes in liver or kidney examined by the same method. Generally stable myocyte cross-sectional area and density indicated that muscle remodelling is well regulated in this hibernator, despite vastly altered seasonal fuel and activity levels. Body composition analysis by echo MRI showed lean tissue preservation throughout hibernation amid declining fat mass by the end of winter. Muscle protein synthesis was 66% depressed in early but not late winter compared with a summer fasted baseline, while no significant changes were observed in the heart, liver or intestine, providing evidence that could support a transition in skeletal muscle regulation between early and late winter, prior to spring emergence and re-feeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.