ArticleThe EMBO journal2015
Receptor guanylyl cyclase-G is a novel thermosensory protein activated by cool temperatures.
Article in The EMBO journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Membrane-bound guanylyl cyclase-G deficiency impairs nitric oxide-mediated epithelial repair in intestinal ischemia-reperfusion injury in male mice.Scientific reports · 2026Article
- A Glial Hub-and-Spoke Circuitry in C. elegans orchestrates bidirectional thermosensation.Nature communications · 2026Article
- Understanding animal temperature sensation: from molecular thermosensors to physiological impacts.Science China. Life sciences · 2026Review
- Ion channels of cold transduction and transmission.The Journal of general physiology · 2024Review
- Early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene Magel2.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Multilimbed membrane guanylate cyclase signaling system, evolutionary ladder.Frontiers in molecular neuroscience · 2022Review
- cGMP dynamics that underlies thermosensation in temperature-sensing neuron regulates thermotaxis behavior in C. elegans.PloS one · 2022Article
- Temperature Sensation: From Molecular Thermosensors to Neural Circuits and Coding Principles.Annual review of physiology · 2021Review
- Olfactory subsystems associated with the necklace glomeruli in rodents.Cell and tissue research · 2021Review
- The Grueneberg ganglion: signal transduction and coding in an olfactory and thermosensory organ involved in the detection of alarm pheromones and predator-secreted kairomones.Cell and tissue research · 2021Review
- Homogeneous single-label cGMP detection platform for the functional study of nitric oxide-sensitive (soluble) guanylyl cyclases and cGMP-specific phosphodiesterases.Scientific reports · 2020Article
- Advances, Perspectives and Potential Engineering Strategies of Light-Gated Phosphodiesterases for Optogenetic Applications.International journal of molecular sciences · 2020Review
- The Impact of Cold Storage on Adenosine Diphosphate-Mediated Platelet Responsiveness.TH open : companion journal to thrombosis and haemostasis · 2020Article
- Article
- HowGenetics · 2019Review
- The extraordinary AFD thermosensor of C. elegans.Pflugers Archiv : European journal of physiology · 2018Review
- Integration of Plasticity Mechanisms within a Single Sensory Neuron of C. elegans Actuates a Memory.Neuron · 2018Article
- Guanylyl cyclase-G is an alarm pheromone receptor in mice.The EMBO journal · 2018Article
- Grueneberg Glomeruli in the Olfactory Bulb are Activated by Odorants and Cool Temperature.Cellular and molecular neurobiology · 2017Article
- Olfaction and Pheromones: Uncanonical Sensory Influences and Bulbar Interactions.Frontiers in neuroanatomy · 2017Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transmembrane guanylyl cyclases (GCs), with activity regulated by peptide ligands and/or calcium-binding proteins, are essential for various physiological and sensory processes. The mode of activation of the GC subtype GC-G, which is expressed in neurons of the Grueneberg ganglion that respond to cool temperatures, has been elusive. In searching for appropriate stimuli to activate GC-G, we found that its enzymatic activity is directly stimulated by cool temperatures. In this context, it was observed that dimerization/oligomerization of GC-G, a process generally considered as critical for enzymatic activity of GCs, is strongly enhanced by coolness. Moreover, heterologous expression of GC-G in cultured cells rendered these cells responsive to coolness; thus, the protein might be a sensor for cool temperatures. This concept is supported by the observation of substantially reduced coolness-induced response of Grueneberg ganglion neurons and coolness-evoked ultrasonic vocalization in GC-G-deficient mouse pups. GC-G may be a novel thermosensory protein with functional implications for the Grueneberg ganglion, a sensory organ responding to cool temperatures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.