Evidence map›Paper›PMID 25452470›Full record

ArticleHypertension (Dallas, Tex. : 1979)2015

Neurokinin 3 receptor and phosphocholine transferase: missing factors for pathogenesis of C-reactive protein in preeclampsia.

Nicholas F Parchim, Wei Wang, Takayuki Iriyama, Olaide A Ashimi, Athar H Siddiqui, Sean Blackwell, Baha Sibai, Rodney E Kellems, Yang Xia

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
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  10. Review
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  13. Preeclampsia and Pregnancy-Related Hypertensive Disorders.Hypertension (Dallas, Tex. : 1979) · 2016
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Nicholas F ParchimFrom the Departments of Biochemistry and Molecular Biology (N.F.P., W.W. T.I., A.H.S., R.E.K., Y.X.), Obstetrics, Gynecology, and Reproductive Sciences (O.A.A., S.B., B.S.), Graduate School of Biomedical Science (N.F.P., R.E.K. Y.X.), University of Texas, Houston; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China (W.W., Y.X.); Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan (T.I.); and School of Medical Sciences, University of Hyderabad, Gachibowli, Hyderabad, India (A.H.S.).
Wei WangFrom the Departments of Biochemistry and Molecular Biology (N.F.P., W.W. T.I., A.H.S., R.E.K., Y.X.), Obstetrics, Gynecology, and Reproductive Sciences (O.A.A., S.B., B.S.), Graduate School of Biomedical Science (N.F.P., R.E.K. Y.X.), University of Texas, Houston; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China (W.W., Y.X.); Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan (T.I.); and School of Medical Sciences, University of Hyderabad, Gachibowli, Hyderabad, India (A.H.S.).
Takayuki IriyamaFrom the Departments of Biochemistry and Molecular Biology (N.F.P., W.W. T.I., A.H.S., R.E.K., Y.X.), Obstetrics, Gynecology, and Reproductive Sciences (O.A.A., S.B., B.S.), Graduate School of Biomedical Science (N.F.P., R.E.K. Y.X.), University of Texas, Houston; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China (W.W., Y.X.); Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan (T.I.); and School of Medical Sciences, University of Hyderabad, Gachibowli, Hyderabad, India (A.H.S.).
Olaide A AshimiFrom the Departments of Biochemistry and Molecular Biology (N.F.P., W.W. T.I., A.H.S., R.E.K., Y.X.), Obstetrics, Gynecology, and Reproductive Sciences (O.A.A., S.B., B.S.), Graduate School of Biomedical Science (N.F.P., R.E.K. Y.X.), University of Texas, Houston; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China (W.W., Y.X.); Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan (T.I.); and School of Medical Sciences, University of Hyderabad, Gachibowli, Hyderabad, India (A.H.S.).
Athar H SiddiquiFrom the Departments of Biochemistry and Molecular Biology (N.F.P., W.W. T.I., A.H.S., R.E.K., Y.X.), Obstetrics, Gynecology, and Reproductive Sciences (O.A.A., S.B., B.S.), Graduate School of Biomedical Science (N.F.P., R.E.K. Y.X.), University of Texas, Houston; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China (W.W., Y.X.); Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan (T.I.); and School of Medical Sciences, University of Hyderabad, Gachibowli, Hyderabad, India (A.H.S.).
Sean BlackwellFrom the Departments of Biochemistry and Molecular Biology (N.F.P., W.W. T.I., A.H.S., R.E.K., Y.X.), Obstetrics, Gynecology, and Reproductive Sciences (O.A.A., S.B., B.S.), Graduate School of Biomedical Science (N.F.P., R.E.K. Y.X.), University of Texas, Houston; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China (W.W., Y.X.); Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan (T.I.); and School of Medical Sciences, University of Hyderabad, Gachibowli, Hyderabad, India (A.H.S.).
Baha SibaiFrom the Departments of Biochemistry and Molecular Biology (N.F.P., W.W. T.I., A.H.S., R.E.K., Y.X.), Obstetrics, Gynecology, and Reproductive Sciences (O.A.A., S.B., B.S.), Graduate School of Biomedical Science (N.F.P., R.E.K. Y.X.), University of Texas, Houston; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China (W.W., Y.X.); Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan (T.I.); and School of Medical Sciences, University of Hyderabad, Gachibowli, Hyderabad, India (A.H.S.).
Rodney E KellemsFrom the Departments of Biochemistry and Molecular Biology (N.F.P., W.W. T.I., A.H.S., R.E.K., Y.X.), Obstetrics, Gynecology, and Reproductive Sciences (O.A.A., S.B., B.S.), Graduate School of Biomedical Science (N.F.P., R.E.K. Y.X.), University of Texas, Houston; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China (W.W., Y.X.); Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan (T.I.); and School of Medical Sciences, University of Hyderabad, Gachibowli, Hyderabad, India (A.H.S.).
Yang XiaFrom the Departments of Biochemistry and Molecular Biology (N.F.P., W.W. T.I., A.H.S., R.E.K., Y.X.), Obstetrics, Gynecology, and Reproductive Sciences (O.A.A., S.B., B.S.), Graduate School of Biomedical Science (N.F.P., R.E.K. Y.X.), University of Texas, Houston; Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan, China (W.W., Y.X.); Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan (T.I.); and School of Medical Sciences, University of Hyderabad, Gachibowli, Hyderabad, India (A.H.S.). yang.xia@uth.tmc.edu.
The University of Tokyo · JPCentral South University · CN

Funding

PURINE METABOLISM AT THE MATERNAL/FETAL INTERFACER01HD034130 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KELLEMS, RODNEY E · 1996 to 2012
$2.8M
Center for Clinical and Translational Sciences (CCTS)TL1TR000369 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$1.9M
Autoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targetsRC4HD067977 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KELLEMS, RODNEY E, XIA, YANG · 2010 to 2010
$1.8M
Metabolites, Sickle Cell Disease, and Novel TherapeuticsR01HL113574 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIA, YANG · 2013 to 2016
$1.5M
Adenosine Signaling, Priapism and Sickle Cell DiseaseR01DK083559 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIA, YANG · 2009 to 2012
$1.3M
AT1 Receptor Activating Autoantibodies and PreeclampsiaR01HL076558 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIA, YANG · 2005 to 2008
$1.0M
Angiotensin Receptor Autoantibodies and PreeclampsiaR56HD034130 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KELLEMS, RODNEY E · 2007 to 2007
$371k
NCATS NIH HHS TL1 TR000369NHLBI NIH HHS HL119549NHLBI NIH HHS R01 HL076558NHLBI NIH HHS R01 HL113574NICHD NIH HHS HD34130NICHD NIH HHS R01 HD034130NICHD NIH HHS R56 HD034130NICHD NIH HHS RC4 HD067977NICHD NIH HHS RC4HD067977NIDDK NIH HHS R01 DK083559
6 · The paper itself

Abstract

C-reactive protein (CRP), an innate immune mediator, is elevated in the circulation before symptoms in patients with preeclampsia, a severe hypertensive pregnancy disorder with high mortality and morbidity. However, the specific sources underlying increased CRP and the role of elevated CRP in preeclampsia are undefined. Here, we report that circulating CRP levels are significantly increased in a large cohort of normotensive pregnant individuals when compared with nulligravid women and is further increased in patients with preeclampsia. These findings led us to discover further that placental syncytiotrophoblasts are previously unrecognized cellular sources of CRP and underlie elevated CRP in normotensive pregnant women and the additional increase in patients with preeclampsia. Next, we demonstrated that injection of CRP induces preeclampsia features, including hypertension (157 mm Hg CRP treated versus 119 mm Hg control), proteinuria (35.0 mg/μg CRP treated versus 14.1 mg/μg control), kidney, and placental damage and increased levels of sFlt-1 in pregnant mice but not in nonpregnant mice. Our study implicates that phosphocholine transferase, a placental-specific enzyme post-translationally modifying neurokinin B, is essential for the pathogenic role of CRP in preeclampsia through activation of the neurokinin 3 receptor. Overall, our studies have provided significant new insight on the pathogenic role of CRP in preeclampsia and highlighted innovative therapeutic strategies.

Indexed as

AnimalsBiomarkersCholine-Phosphate CytidylyltransferaseC-Reactive ProteinDisease Models, AnimalDouble-Blind MethodFemaleHumansKidneyMiceMice, Inbred C57BLNeurokinin BPhosphorylationPhosphorylcholinePlacentaPre-EclampsiaBiomarkersCholine-Phosphate CytidylyltransferaseC-Reactive ProteinCTP phosphocholine cytidylyltransferase, beta isoform, mouseFLT1 protein, humanNeurokinin BPCYT1B protein, humanPhosphorylcholineQuinolinesReceptors, Neurokinin-3Recombinant ProteinsRNA, Small InterferingSB 222200Vascular Endothelial Growth Factor Receptor-1C-reactive proteininflammationneurokinin Bphosphocholine transferase

Identifiers

PMID25452470
PMCPMC4736731
OpenAlexW1966777009

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.