Evidence map›Paper›PMID 25452455›Full record

GuidelineJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015

Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Clinical Practice Guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology Clinical Practice Guidelines.

Elena M Stoffel, Pamela B Mangu, Stephen B Gruber, Stanley R Hamilton, Matthew F Kalady, Michelle Wan Yee Lau, Karen H Lu, Nancy Roach, Paul J Limburg, American Society of Clinical Oncology and 1 more

Registry-linked trialAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02951390 (High Definition White-Light Colonoscopy Versus Chromoendoscopy for Surveillance of Lynch Syndrome. A Prospective, Multicenter and Randomized Study), which is not on this map. Cited by 158 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 3 pooled it
21.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02951390 nacompletednot on this mapstarted 2016, after this paper: background citation

High Definition White-Light Colonoscopy Versus Chromoendoscopy for Surveillance of Lynch Syndrome. A Prospective, Multicenter and Randomized Study

TypeinterventionalSponsorHospital Clinic of BarcelonaRan2016 to 2017Enrolled280ConditionsLynch SyndromeArmsHigh-definition white-light endoscopy
3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 3 syntheses or guidelines pooled it, 369 citations in OpenAlex.

  1. Guideline
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  20. Predictive Genetic Testing in the Cancer Management and Prevention.Journal of cancer science and clinical therapeutics · 2025
    Article

98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Elena M StoffelElena M. Stoffel, University of Michigan, Ann Arbor, MI; Pamela B. Mangu, American Society of Clinical Oncology; Nancy Roach, Fight Colorectal Cancer, Alexandria, VA; Stephen B. Gruber, University of Southern California, Los Angeles, CA; Stanley R. Hamilton and Karen H. Lu, University of Texas MD Anderson Cancer Center, Houston, TX; Matthew F. Kalady, Cleveland Clinic, Cleveland, OH; Michelle Wan Yee Lau, Integrated Medical Services Four Winds Hematology and Oncology, Tempe, AZ; and Paul J. Limburg, Mayo Clinic, Rochester, MN.
Pamela B ManguElena M. Stoffel, University of Michigan, Ann Arbor, MI; Pamela B. Mangu, American Society of Clinical Oncology; Nancy Roach, Fight Colorectal Cancer, Alexandria, VA; Stephen B. Gruber, University of Southern California, Los Angeles, CA; Stanley R. Hamilton and Karen H. Lu, University of Texas MD Anderson Cancer Center, Houston, TX; Matthew F. Kalady, Cleveland Clinic, Cleveland, OH; Michelle Wan Yee Lau, Integrated Medical Services Four Winds Hematology and Oncology, Tempe, AZ; and Paul J. Limburg, Mayo Clinic, Rochester, MN.
Stephen B GruberElena M. Stoffel, University of Michigan, Ann Arbor, MI; Pamela B. Mangu, American Society of Clinical Oncology; Nancy Roach, Fight Colorectal Cancer, Alexandria, VA; Stephen B. Gruber, University of Southern California, Los Angeles, CA; Stanley R. Hamilton and Karen H. Lu, University of Texas MD Anderson Cancer Center, Houston, TX; Matthew F. Kalady, Cleveland Clinic, Cleveland, OH; Michelle Wan Yee Lau, Integrated Medical Services Four Winds Hematology and Oncology, Tempe, AZ; and Paul J. Limburg, Mayo Clinic, Rochester, MN.
Stanley R HamiltonElena M. Stoffel, University of Michigan, Ann Arbor, MI; Pamela B. Mangu, American Society of Clinical Oncology; Nancy Roach, Fight Colorectal Cancer, Alexandria, VA; Stephen B. Gruber, University of Southern California, Los Angeles, CA; Stanley R. Hamilton and Karen H. Lu, University of Texas MD Anderson Cancer Center, Houston, TX; Matthew F. Kalady, Cleveland Clinic, Cleveland, OH; Michelle Wan Yee Lau, Integrated Medical Services Four Winds Hematology and Oncology, Tempe, AZ; and Paul J. Limburg, Mayo Clinic, Rochester, MN.
Matthew F KaladyElena M. Stoffel, University of Michigan, Ann Arbor, MI; Pamela B. Mangu, American Society of Clinical Oncology; Nancy Roach, Fight Colorectal Cancer, Alexandria, VA; Stephen B. Gruber, University of Southern California, Los Angeles, CA; Stanley R. Hamilton and Karen H. Lu, University of Texas MD Anderson Cancer Center, Houston, TX; Matthew F. Kalady, Cleveland Clinic, Cleveland, OH; Michelle Wan Yee Lau, Integrated Medical Services Four Winds Hematology and Oncology, Tempe, AZ; and Paul J. Limburg, Mayo Clinic, Rochester, MN.
Michelle Wan Yee LauElena M. Stoffel, University of Michigan, Ann Arbor, MI; Pamela B. Mangu, American Society of Clinical Oncology; Nancy Roach, Fight Colorectal Cancer, Alexandria, VA; Stephen B. Gruber, University of Southern California, Los Angeles, CA; Stanley R. Hamilton and Karen H. Lu, University of Texas MD Anderson Cancer Center, Houston, TX; Matthew F. Kalady, Cleveland Clinic, Cleveland, OH; Michelle Wan Yee Lau, Integrated Medical Services Four Winds Hematology and Oncology, Tempe, AZ; and Paul J. Limburg, Mayo Clinic, Rochester, MN.
Karen H LuElena M. Stoffel, University of Michigan, Ann Arbor, MI; Pamela B. Mangu, American Society of Clinical Oncology; Nancy Roach, Fight Colorectal Cancer, Alexandria, VA; Stephen B. Gruber, University of Southern California, Los Angeles, CA; Stanley R. Hamilton and Karen H. Lu, University of Texas MD Anderson Cancer Center, Houston, TX; Matthew F. Kalady, Cleveland Clinic, Cleveland, OH; Michelle Wan Yee Lau, Integrated Medical Services Four Winds Hematology and Oncology, Tempe, AZ; and Paul J. Limburg, Mayo Clinic, Rochester, MN.
Nancy RoachElena M. Stoffel, University of Michigan, Ann Arbor, MI; Pamela B. Mangu, American Society of Clinical Oncology; Nancy Roach, Fight Colorectal Cancer, Alexandria, VA; Stephen B. Gruber, University of Southern California, Los Angeles, CA; Stanley R. Hamilton and Karen H. Lu, University of Texas MD Anderson Cancer Center, Houston, TX; Matthew F. Kalady, Cleveland Clinic, Cleveland, OH; Michelle Wan Yee Lau, Integrated Medical Services Four Winds Hematology and Oncology, Tempe, AZ; and Paul J. Limburg, Mayo Clinic, Rochester, MN.
Paul J LimburgElena M. Stoffel, University of Michigan, Ann Arbor, MI; Pamela B. Mangu, American Society of Clinical Oncology; Nancy Roach, Fight Colorectal Cancer, Alexandria, VA; Stephen B. Gruber, University of Southern California, Los Angeles, CA; Stanley R. Hamilton and Karen H. Lu, University of Texas MD Anderson Cancer Center, Houston, TX; Matthew F. Kalady, Cleveland Clinic, Cleveland, OH; Michelle Wan Yee Lau, Integrated Medical Services Four Winds Hematology and Oncology, Tempe, AZ; and Paul J. Limburg, Mayo Clinic, Rochester, MN.
American Society of Clinical Oncology
European Society of Clinical Oncology
American Society of Clinical Oncology · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
6 · The paper itself

Abstract

purposeTo provide recommendations on prevention, screening, genetics, treatment, and management for people at risk for hereditary colorectal cancer (CRC) syndromes. The American Society of Clinical Oncology (ASCO) has a policy and set of procedures for endorsing clinical practice guidelines that have been developed by other professional organizations.

methodsThe Familial Risk-Colorectal Cancer: European Society for Medical Oncology Clinical Practice Guideline published in 2013 on behalf of the European Society for Medical Oncology (ESMO) Guidelines Working Group in Annals of Oncology was reviewed for developmental rigor by methodologists, with content and recommendations reviewed by an ASCO endorsement panel.

resultsThe ASCO endorsement panel determined that the recommendations of the ESMO guidelines are clear, thorough, and based on the most relevant scientific evidence. The ASCO panel endorsed the ESMO guidelines and added a few qualifying statements. RECOMMENDATIONS: Approximately 5% to 6% of patient cases of CRC are associated with germline mutations that confer an inherited predisposition for cancer. The possibility of a hereditary cancer syndrome should be assessed for every patient at the time of CRC diagnosis. A diagnosis of Lynch syndrome, familial adenomatous polyposis, or another genetic syndrome can influence clinical management for patients with CRC and their family members. Screening for hereditary cancer syndromes in patients with CRC should include review of personal and family histories and testing of tumors for DNA mismatch repair deficiency and/or microsatellite instability. Formal genetic evaluation is recommended for individuals who meet defined criteria.

Indexed as

Genetic TestingHeterozygotePopulation SurveillanceAdenomatous Polyposis ColiAdenomatous Polyposis Coli ProteinAnticarcinogenic AgentsChemopreventionColonoscopyColorectal Neoplasms, Hereditary NonpolyposisDNA GlycosylasesDNA Mismatch RepairEarly Detection of CancerGenetic CounselingGenetic Predisposition to DiseaseGerm-Line MutationHumansAdenomatous Polyposis Coli ProteinAnticarcinogenic AgentsAPC protein, humanDNA GlycosylasesmutY adenine glycosylase

Identifiers

PMID25452455
PMCPMC5321096
OpenAlexW2106832044

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.