Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2015
Randomized, double-blind, placebo-controlled, multicenter phase II study of the efficacy and safety of apricoxib in combination with either docetaxel or pemetrexed in patients with biomarker-selected non-small-cell lung cancer.
Abstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
In one paragraph
Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Cardiovascular/anti-inflammatory drugs repurposed for treating or preventing cancer: A systematic review and meta-analysis of randomized trials.Cancer medicine · 2024Pooled it
- Pooled it
- Trial
- Impact of concurrent medications on the outcome of immunotherapy in non-small cell lung carcinoma.Thoracic cancer · 2024Article
- Exo-miR-1290-induced by COX-2 overexpression promotes cancer-associated fibroblasts activation and tumor progression by CUL3-Nrf2 pathway in lung adenocarcinoma.Cell communication and signaling : CCS · 2023Article
- Prognostic implications of prostaglandin E-major urinary metabolite in resected non-small-cell lung cancer.Interdisciplinary cardiovascular and thoracic surgery · 2023Article
- Clinical benefit of COX-2 inhibitors in the adjuvant chemotherapy of advanced non-small cell lung cancer: A systematic review and meta-analysis.World journal of clinical cases · 2021Article
- Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Inhibition of PI3K-AKT Signaling Blocks PGEOncoTargets and therapy · 2020Article
- Proteomics-Based Characterization of miR-574-5p Decoy to CUGBP1 Suggests Specificity for mPGES-1 Regulation in Human Lung Cancer Cells.Frontiers in pharmacology · 2020Article
- Article
- Pooled analysis of the clinical benefit of cyclooxygenase-2 inhibitors combined with chemotherapy in advanced non-small cell lung cancer.Translational cancer research · 2019Article
- Preoperative stimulation of resolution and inflammation blockade eradicates micrometastases.The Journal of clinical investigation · 2019Article
- Prostaglandin E-Major Urinary Metabolite (PGE-MUM) as a Tumor Marker for Lung Adenocarcinoma.Cancers · 2019Article
- Celecoxib With Neoadjuvant Chemotherapy for Breast Cancer Might Worsen Outcomes Differentially by COX-2 Expression and ER Status: Exploratory Analysis of the REMAGUS02 Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2019Article
- Efficacy and safety of COX-2 inhibitors for advanced non-small-cell lung cancer with chemotherapy: a meta-analysis.OncoTargets and therapy · 2018Article
- Article
- Revisiting the role of COX-2 inhibitor for non-small cell lung cancer.Translational lung cancer research · 2015Article
- Therapeutic Effects of Repurposed Therapies in Non-Small Cell Lung Cancer: What Is Old Is New Again.The oncologist · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Martin J EdelmanMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA. medelman@umm.edu.
Ming T TanMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Mary J FidlerMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Rachel E SanbornMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Greg OttersonMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Lecia V SequistMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Tracey L EvansMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Bryan J SchneiderMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Roger KeresztesMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
John S RogersMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Jorge Antunez de MayoloMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Josephine FelicianoMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Yang YangMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Michelle MedeirosMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Sara L ZaknoenMartin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University of Pennsylvania, Philadelphia, PA; Bryan J. Schneider, Weill Cornell Medical College, New York City; Roger Keresztes, State University of New York Stony Brook, Stony Brook, NY; John S. Rogers, West Virginia University School of Medicine, Morgantown, WV; Jorge Antunez de Mayolo, Mercy Research Institute, Miami, FL; and Sara L. Zaknoen, Tragara, San Diego, CA.
Georgetown University · USMercy Research · US
Funding
UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0MNCI NIH HHS P30 CA134274
Abstract
purposeOverexpression of COX-2 correlates with advanced stage and worse outcomes in non-small-cell lung cancer (NSCLC), possibly as a result of elevated levels of COX-2-dependent prostaglandin E2 (PGE2). Exploratory analyses of studies that used COX-2 inhibitors have demonstrated potentially superior outcome in patients in whom the urinary metabolite of PGE2 (PGE-M) is suppressed. We hypothesized that patients with disease defined by PGE-M suppression would benefit from the addition of apricoxib to second-line docetaxel or pemetrexed. PATIENTS AND
methodsPatients with NSCLC who had disease progression after one line of platinum-based therapy, performance status of 0 to 2, and normal organ function were potentially eligible. Only patients with a ≥ 50% decrease in urinary PGE-M after 5 days of treatment with apricoxib could enroll. Docetaxel 75 mg/m(2) or pemetrexed 500 mg/m(2) once every 21 days per the investigator was administered with apricoxib or placebo 400 mg once per day. The primary end point was progression-free survival (PFS). Exploratory analysis was performed regarding baseline urinary PGE-M and outcomes.
resultsIn all, 101 patients completed screening, and 72 of the 80 who demonstrated ≥ 50% suppression were randomly assigned to apricoxib or placebo. Toxicity was similar between the arms. No improvement in PFS was seen with apricoxib versus placebo. The median PFS for the control arm was 97 days (95% CI, 52 to 193 days) versus 85 days (95% CI, 67 to 142 days) for the experimental arm (P = .91).
conclusionApricoxib did not improve PFS, despite biomarker-driven patient selection.
Indexed as
AgedAntineoplastic Combined Chemotherapy ProtocolsBiomarkers, TumorCarcinoma, Non-Small-Cell LungCyclooxygenase 2Disease-Free SurvivalDocetaxelDouble-Blind MethodDrug Administration ScheduleFemaleGlutamatesGuanineHumansKaplan-Meier EstimateLung NeoplasmsMale7-hydroxy-5,11-dioxotetranorprostane-1,16-dioic acidapricoxibBiomarkers, TumorCyclooxygenase 2DocetaxelGlutamatesGuaninePemetrexedProstaglandinsPTGS2 protein, humanPyrrolesSulfonamidesTaxoids
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