ArticleNucleic acids research2015
Comparative genomic analysis of Helicobacter pylori from Malaysia identifies three distinct lineages suggestive of differential evolution.
Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Antibiotic Resistance and Genetic Determinants ofInternational journal of molecular sciences · 2025Article
- Beyond Low Prevalence: Exploring Antibiotic Resistance and Virulence Profiles in Sri Lankan Helicobacter pylori with Comparative Genomics.Microorganisms · 2025Article
- The Helicobacter pylori Genome Project: insights into H. pylori population structure from analysis of a worldwide collection of complete genomes.Nature communications · 2023Article
- A Survey ofAntimicrobial agents and chemotherapy · 2022Article
- Genome Dynamics and Evolution of Multiple-Drug-Resistant Bacteria: Implications for Global Infection Control Priorities.The Journal of infectious diseases · 2021Article
- Genomic population structure ofVirulence · 2021Article
- Shedding Light on the African Enigma: In Vitro Testing ofMicroorganisms · 2021Article
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- Helicobacter pylori Infections in the Bronx, New York: Surveying Antibiotic Susceptibility and Strain Lineage by Whole-Genome Sequencing.Journal of clinical microbiology · 2020Article
- A novel taxon selection method, aimed at minimizing recombination, clarifies the discovery of a new sub-population ofEvolutionary applications · 2020Article
- Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease.Genome biology and evolution · 2018Article
- Review
- Draft Genome Sequences of 42Genome announcements · 2018Article
- [Research progress on genotyping ofZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2018Review
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- Whole Genome Sequence and Phylogenetic Analysis ShowFrontiers in cellular and infection microbiology · 2017Article
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- Phylogenomics of ColombianGut pathogens · 2017Article
- Multipronged regulatory functions of a novel endonuclease (TieA) from Helicobacter pylori.Nucleic acids research · 2016Article
- Identification of a Latin American-specific BabA adhesin variant through whole genome sequencing of Helicobacter pylori patient isolates from Nicaragua.BMC evolutionary biology · 2016Article
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13 authors.
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Abstract
The discordant prevalence of Helicobacter pylori and its related diseases, for a long time, fostered certain enigmatic situations observed in the countries of the southern world. Variation in H. pylori infection rates and disease outcomes among different populations in multi-ethnic Malaysia provides a unique opportunity to understand dynamics of host-pathogen interaction and genome evolution. In this study, we extensively analyzed and compared genomes of 27 Malaysian H. pylori isolates and identified three major phylogeographic lineages: hspEastAsia, hpEurope and hpSouthIndia. The analysis of the virulence genes within the core genome, however, revealed a comparable pathogenic potential of the strains. In addition, we identified four genes limited to strains of East-Asian lineage. Our analyses identified a few strain-specific genes encoding restriction modification systems and outlined 311 core genes possibly under differential evolutionary constraints, among the strains representing different ethnic groups. The cagA and vacA genes also showed variations in accordance with the host genetic background of the strains. Moreover, restriction modification genes were found to be significantly enriched in East-Asian strains. An understanding of these variations in the genome content would provide significant insights into various adaptive and host modulation strategies harnessed by H. pylori to effectively persist in a host-specific manner.
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