Evidence map›Paper›PMID 25452300›Full record

Trial reportAmerican journal of hypertension2015

Should Blood Pressure Targets After Lacunar Stroke Vary by Body Size? The SPS3 Trial.

Thalia S Field, Leslie A McClure, Carole L White, Pablo E Pergola, Robert G Hart, Oscar R Benavente, Michael D Hill, SPS3 Investigators

Registry-linked trialOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00059306 (Secondary Prevention of Small Subcortical Strokes), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00059306 phase3completednot on this map

Secondary Prevention of Small Subcortical Strokes (SPS3) Trial

TypeinterventionalSponsorUniversity of British ColumbiaRan2003 to 2012Enrolled3,020ConditionsCerebrovascular Accident, HypertensionArmsaspirin, clopidogrel, Target of Blood Pressure, placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Thalia S FieldCentre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada; thalia.field@ubc.ca.
Leslie A McClureDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama;
Carole L WhiteUniversity of Texas Health Sciences Center at San Antonio, San Antonio, Texas;
Pablo E PergolaUniversity of Texas Health Sciences Center at San Antonio, San Antonio, Texas;
Robert G HartPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada;
Oscar R BenaventeCentre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada;
Michael D HillHotchkiss Brain Center, Department of Neurosciences, University of Calgary, Calgary, Alberta, Canada.
SPS3 Investigators
The University of Texas Health Science Center at San Antonio · USUniversity of British Columbia · CAPopulation Health Research Institute · CAUniversity of Alabama at Birmingham · US

Funding

SECONDARY PREVENTION OF SMALL SUBCORTICAL STROKES (SPSS)U01NS038529 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BENAVENTE, OSCAR R · 2003 to 2012
$62.9M
Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
NCATS NIH HHS UL1 TR000439NINDS NIH HHS U01 NS038529NINDS NIH HHS U01NS038529
6 · The paper itself

Abstract

backgroundIt is unknown whether the physiological impact of a given blood pressure (BP) varies by body size. We explored interactions between higher vs. lower systolic BP (SBP) targets and anthropometric measures (body mass index (BMI), body surface area (BSA), height, weight) and recurrent stroke and death in the Secondary Prevention of Small Subcortical Strokes (SPS3) Trial.

methodsPatients with recent magnetic resonance imaging-proven lacunar infarcts were randomized to 2 BP targets (130-149 mm Hg vs. <130) in a prospective, open-label, blinded end-point design. Time to outcome was evaluated with Cox proportional hazard models and compared between targets. We examined multiplicative interactions between each anthropometric measure and target and mean difference in achieved BP 1 year after randomization between BP groups by quartile. We also computed rates of recurrent stroke and death by quartiles of anthropometrics.

resultsThree thousand and twenty patients were followed over a mean of 3.7 (SD 2.0) years. Mean age was 63; 63% were male. Mean height was 167 (SD 11) cm, weight 81 (18) kg, BMI 29 (5.9) kg/m(2), and BSA 1.9 (0.25) m(2). Achieved BP at 1 year was comparable between quartiles for each anthropometric measurement. We found no consistent interactions between BP target and anthropometrics for either outcome, nor were there any significant associations between hazard of stroke or death when assessed by BMI, BSA, height, or weight.

conclusionsWe found no interactions between BP target groups and quartiles of anthropometrics for rates of stroke and death in SPS3. There is no evidence at this time supporting body size-based modifications to current BP targets for secondary prevention after lacunar stroke. CLINICAL TRIALS REGISTRATION: Trial Number NCT00059306.

Indexed as

Body Mass IndexBody SizeBody Surface AreaHypertensionStroke, LacunarAgedAntihypertensive AgentsBlood Pressure DeterminationDrug Therapy, CombinationFemaleHumansMaleMiddle AgedPrognosisProportional Hazards ModelsRecurrenceAntihypertensive Agentsblood pressureBMIbody sizeBSAheighthypertensionlacunar strokeprognosissecondary preventionweight.

Identifiers

PMID25452300
PMCPMC4447819
OpenAlexW2146637983

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.