ArticleApplied and environmental microbiology2015
Inactivation of murine norovirus on a range of copper alloy surfaces is accompanied by loss of capsid integrity.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 120 citations in OpenAlex.
- Trial
- Plasma Functionalization Enables Diffusion Control of Reactive Oxygen Species.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Virucidal Efficacy of Laser-Generated Copper Nanoparticle Coatings against Model Coronavirus and Herpesvirus.ACS applied materials & interfaces · 2025Article
- Public surface disinfection every 2 hours can reduce the infection risk of norovirus in airports up to 83.PLoS computational biology · 2024Article
- Impact of Nanoparticle-Based TiOFoods (Basel, Switzerland) · 2024Article
- Cu-based thin rolled foils: relationship among alloy composition, micromechanical and antiviral properties against SARS-CoV-2.Heliyon · 2024Article
- A Long-Term Study on the Bactericidal Effect of ZrN-Cu Nanostructured Coatings Deposited by an Industrial Physical Vapor Deposition System.Nanomaterials (Basel, Switzerland) · 2024Article
- Article
- Toxicity Mechanisms of Copper Nanoparticles and Copper Surfaces on Bacterial Cells and Viruses.International journal of molecular sciences · 2023Review
- Biogenic production of silver, zinc oxide, and cuprous oxide nanoparticles, and their impregnation into textiles with antiviral activity against SARS-CoV-2.Scientific reports · 2023Article
- Tackling COVID-19 Using Antiviral Nanocoating's-Recent Progress and Future Challenges.Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems · 2023Review
- Antimicrobial activity of silver-copper coating against aerosols containing surrogate respiratory viruses and bacteria.PloS one · 2023Article
- Antibacterial and Virucidal Evaluation of Ultrafine Wire Arc Sprayed German Silver Coatings.Journal of thermal spray technology · 2023Review
- Mitigation of SARS-CoV-2 by Using Transition Metal Nanozeolites and Quaternary Ammonium Compounds as Antiviral Agents in Suspensions and Soft Fabric Materials.International journal of nanomedicine · 2023Article
- Computer Simulation of the Interaction between SARS-CoV-2 Spike Protein and the Surface of Coinage Metals.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- Antiviral Polymer Brushes by Visible-Light-Induced, Oxygen-Tolerant Covalent Surface Coating.ACS omega · 2022Article
- Antibacterial Activity of Copper Particles Embedded in Knitted Fabrics.Materials (Basel, Switzerland) · 2022Article
- Effect of Cu Modified Textile Structures on Antibacterial and Antiviral Protection.Materials (Basel, Switzerland) · 2022Article
- Efficacy and Mechanisms of Copper Ion-Catalyzed Inactivation of Human Norovirus.ACS infectious diseases · 2022Article
- Residual antimicrobial coating efficacy against SARS-CoV-2.Journal of applied microbiology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Norovirus is one of the most common causes of acute viral gastroenteritis. The virus is spread via the fecal-oral route, most commonly from infected food and water, but several outbreaks have originated from contamination of surfaces with infectious virus. In this study, a close surrogate of human norovirus causing gastrointestinal disease in mice, murine norovirus type 1 (MNV-1), retained infectivity for more than 2 weeks following contact with a range of surface materials, including Teflon (polytetrafluoroethylene [PTFE]), polyvinyl chloride (PVC), ceramic tiles, glass, silicone rubber, and stainless steel. Persistence was slightly prolonged on ceramic surfaces. A previous study in our laboratory observed that dry copper and copper alloy surfaces rapidly inactivated MNV-1 and destroyed the viral genome. In this new study, we have observed that a relatively small change in the percentage of copper, between 70 and 80% in copper nickels and 60 and 70% in brasses, had a significant influence on the ability of the alloy to inactivate norovirus. Nickel alone did not affect virus, but zinc did have some antiviral effect, which was synergistic with copper and resulted in an increased efficacy of brasses with lower percentages of copper. Electron microscopy of purified MNV-1 that had been exposed to copper and stainless steel surfaces suggested that a massive breakdown of the viral capsid had occurred on copper. In addition, MNV-1 that had been exposed to copper and treated with RNase demonstrated a reduction in viral gene copy number. This suggests that capsid integrity is compromised upon contact with copper, allowing copper ion access to the viral genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.