ArticleGenes & development2014
Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation.
Article in Genes & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- N-terminus ofeLife · 2024Article
- The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization.Cellular and molecular life sciences : CMLS · 2024Article
- Interaction of MLE with CLAMP zinc finger is involved in proper MSL proteins binding to chromosomes inOpen biology · 2024Article
- Investigation of protein family relationships with deep learning.Bioinformatics advances · 2024Article
- Dosage Compensation inInternational journal of molecular sciences · 2022Review
- Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.Nucleic acids research · 2022Article
- Chlamydomonas CHT7 is involved in repressing DNA replication and mitotic genes during synchronous growth.G3 (Bethesda, Md.) · 2022Article
- Divergent evolution toward sex chromosome-specific gene regulation inGenes & development · 2021Article
- Article
- Modulation of CHT7 Complexes during Light/Dark- and Nitrogen-Mediated Life Cycle Transitions of Chlamydomonas.Plant physiology · 2020Article
- Chlamydomonas CHT7 Is Required for an Effective Quiescent State by Regulating Nutrient-Responsive Cell Cycle Gene Expression.The Plant cell · 2020Article
- Progressive dosage compensation during Drosophila embryogenesis is reflected by gene arrangement.EMBO reports · 2019Article
- Factor cooperation for chromosome discrimination in Drosophila.Nucleic acids research · 2019Article
- Identification and Functional Characterization of a New Splicing Variant of EZH2 in the Central Nervous System.International journal of biological sciences · 2019Article
- Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells.Nature communications · 2018Article
- Transcriptional modulation of entire chromosomes: dosage compensation.Journal of genetics · 2018Review
- Differential Occupancy of Two GA-Binding Proteins Promotes Targeting of the Drosophila Dosage Compensation Complex to the Male X Chromosome.Cell reports · 2018Article
- Article
- Dosage Compensation in Drosophila-a Model for the Coordinate Regulation of Transcription.Genetics · 2016Review
- Article
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
The male-specific lethal dosage compensation complex (MSL-DCC) selectively assembles on the X chromosome in Drosophila males and activates gene transcription by twofold through histone acetylation. An MSL recognition element (MRE) sequence motif nucleates the initial MSL association, but how it is recognized remains unknown. Here, we identified the CXC domain of MSL2 specifically recognizing the MRE motif and determined its crystal structure bound to specific and nonspecific DNAs. The CXC domain primarily contacts one strand of DNA duplex and employs a single arginine to directly read out dinucleotide sequences from the minor groove. The arginine is flexible when bound to nonspecific sequences. The core region of the MRE motif harbors two binding sites on opposite strands that can cooperatively recruit a CXC dimer. Specific DNA-binding mutants of MSL2 are impaired in MRE binding and X chromosome localization in vivo. Our results reveal multiple dynamic DNA-binding modes of the CXC domain that target the MSL-DCC to X chromosomes.
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