Evidence map›Paper›PMID 25452270›Full record

ReviewGenes & development2014

So many pieces, one puzzle: cell type specification and visual circuitry in flies and mice.

Mathias F Wernet, Andrew D Huberman, Claude Desplan

Open access · diamondAbstract readReview
In one paragraph

Review in Genes & development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Tunable dual-AAV sparse labeling of PVFrontiers in neural circuits · 2025
    Article
  3. Behavioral responses of free-flying Drosophila melanogaster to shiny, reflecting surfaces.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023
    Article
  4. Article
  5. Article
  6. Article
  7. Distinct expression of potassium channels regulates visual response properties of lamina neurons in Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020
    Article
  8. Development (Cambridge, England) · 2018
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Mathias F WernetDepartment of Neurobiology, Stanford University, Stanford, California 94305, USA; New York University Abu Dhabi, Saadiyat Island, Abu Dhabi 129188, United Arab Emirates; Department of Biology, New York University, New York, New York 10003, USA;
Andrew D HubermanDepartment of Neurosciences, Neurobiology Section, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093, USA.
Claude DesplanNew York University Abu Dhabi, Saadiyat Island, Abu Dhabi 129188, United Arab Emirates; Department of Biology, New York University, New York, New York 10003, USA;
New York University · USNew York University Abu Dhabi · AEUniversity of California, San Diego · US

Funding

Signaling from photoreceptors to the optic lobesR01EY013012 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2024
$9.4M
Stochastic choices in the retina and optic lobesR01EY013010 · NEI · NEW YORK UNIVERSITY · PI DESPLAN, CLAUDE · 1999 to 2025
$9.1M
NEI NIH HHS R01 EY013010NEI NIH HHS R01 EY013012
6 · The paper itself

Abstract

The visual system is a powerful model for probing the development, connectivity, and function of neural circuits. Two genetically tractable species, mice and flies, are together providing a great deal of understanding of these processes. Current efforts focus on integrating knowledge gained from three cross-fostering fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types ("connectomics") by high-resolution three-dimensional circuit anatomy, and (3) causal testing of how identified circuit elements contribute to visual perception and behavior. Here we discuss representative examples from fly and mouse models to illustrate the ongoing success of this tripartite strategy, focusing on the ways it is enhancing our understanding of visual processing and other sensory systems.

Indexed as

AnimalsBehavior, AnimalCell DifferentiationDrosophilaMiceModels, AnimalRetinaVision, OcularVisual Perceptioncell typescircuitryfunctionvision

Identifiers

PMID25452270
PMCPMC4248288
OpenAlexW2117589111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.