Evidence map›Paper›PMID 25452219›Full record

GuidelineEuropean journal of nuclear medicine and molecular imaging2015

FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0.

Ronald Boellaard, Roberto Delgado-Bolton, Wim J G Oyen, Francesco Giammarile, Klaus Tatsch, Wolfgang Eschner, Fred J Verzijlbergen, Sally F Barrington, Lucy C Pike, Wolfgang A Weber and 19 more

2 registry-linked trialsAbstract readGuideline
In one paragraph

Guideline in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1,726 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,726citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04046237 narecruitingnot on this mapstarted 2019, after this paper: background citation

Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2019 to 2028Enrolled210ConditionsAcute Myocardial Infarction, Severe Periodontitis, Carotid AtherosclerosisArmsPeriodontal treatment
NCT05037799 active not recruitingnot on this mapstarted 2022, after this paper: background citation

Optimization of Image Quality for Myocardial Perfusion Imaging With Rubidium-82 PET in Patients With Known or Suspected Ischemic Heart Disease (RUBY-DOSE)

Typeobservational_patient_registrySponsorOttawa Heart Institute Research CorporationRan2022 to 2026Enrolled48ConditionsIschemic Heart DiseaseArmsRb-82 Radioisotope
3 · Its place in the literature

Who cites it

1,726 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Progression-free survival prediction and comparative metastasis detection accuracy ofEuropean journal of nuclear medicine and molecular imaging · 2026
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  12. Article
  13. Review
  14. Impact of biguanide therapy on hepaticAnnals of nuclear medicine · 2026
    Article
  15. Article
  16. Biological effects ofEuropean radiology · 2026
    Observational
  17. Omitting Bone Marrow Sampling in FDG-Avid Rhabdomyosarcoma With 2-[Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
    Observational
  18. Article
  19. Article
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1,666 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Ronald BoellaardDepartment of Radiology & Nuclear Medicine, VU University Medical Centre, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands, r.boellaard@vumc.nl.
Roberto Delgado-Bolton
Wim J G Oyen
Francesco Giammarile
Klaus Tatsch
Wolfgang Eschner
Fred J Verzijlbergen
Sally F Barrington
Lucy C Pike
Wolfgang A Weber
Sigrid Stroobants
Dominique Delbeke
Kevin J Donohoe
Scott Holbrook
Michael M Graham
Giorgio Testanera
Otto S Hoekstra
Josee Zijlstra
Eric Visser
Corneline J Hoekstra
Jan Pruim
Antoon Willemsen
Bertjan Arends
Jörg Kotzerke
Andreas Bockisch
Thomas Beyer
Arturo Chiti
Bernd J Krause
European Association of Nuclear Medicine (EANM)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of these guidelines is to assist physicians in recommending, performing, interpreting and reporting the results of FDG PET/CT for oncological imaging of adult patients. PET is a quantitative imaging technique and therefore requires a common quality control (QC)/quality assurance (QA) procedure to maintain the accuracy and precision of quantitation. Repeatability and reproducibility are two essential requirements for any quantitative measurement and/or imaging biomarker. Repeatability relates to the uncertainty in obtaining the same result in the same patient when he or she is examined more than once on the same system. However, imaging biomarkers should also have adequate reproducibility, i.e. the ability to yield the same result in the same patient when that patient is examined on different systems and at different imaging sites. Adequate repeatability and reproducibility are essential for the clinical management of patients and the use of FDG PET/CT within multicentre trials. A common standardised imaging procedure will help promote the appropriate use of FDG PET/CT imaging and increase the value of publications and, therefore, their contribution to evidence-based medicine. Moreover, consistency in numerical values between platforms and institutes that acquire the data will potentially enhance the role of semiquantitative and quantitative image interpretation. Precision and accuracy are additionally important as FDG PET/CT is used to evaluate tumour response as well as for diagnosis, prognosis and staging. Therefore both the previous and these new guidelines specifically aim to achieve standardised uptake value harmonisation in multicentre settings.

Indexed as

Fluorodeoxyglucose F18RadiopharmaceuticalsHumansMultimodal ImagingNeoplasmsPositron-Emission TomographyTomography, X-Ray ComputedFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID25452219
PMCPMC4315529

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.