ArticleJournal of affective disorders2015
Clinical, cognitive, and functional connectivity correlations of resting-state intrinsic brain activity alterations in unmedicated depression.
Article in Journal of affective disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
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Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Neural mechanisms of suicide thoughts and behaviors in major depressive disorder: abnormal regional brain activity and its functional connectivity.BMC psychiatry · 2025Pooled it
- Disruptive resting state networks characterizing depressive comorbidity in Alzheimer's disease and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Pooled it
- ΔBiological psychiatry. Cognitive neuroscience and neuroimaging · 2026Trial
- Altered gray matter volume in major depressive disorder patients with psychomotor retardation.Neuroreport · 2026Article
- Neptune: a toolbox for spinal cord functional MRI data processing and quality assurance.bioRxiv : the preprint server for biology · 2026Article
- The association between gut microbiota and functional connectivity in cognitive impairment of first-episode major depressive disorder.Translational psychiatry · 2025Article
- Concurrent functional-structural reorganization in brain networks of AVM patients: a functional and structural study.Frontiers in neurology · 2025Article
- Alterations of regional brain activity and corresponding brain circuits in drug-naïve adolescents with nonsuicidal self-injury.Scientific reports · 2024Article
- Rumination and Overrecruitment of Cognitive Control Circuits in Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder.Journal of Zhejiang University. Science. B · 2024Article
- The Effects of Variation in the GABANeuropsychiatric disease and treatment · 2024Article
- Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography.Journal of biomedical optics · 2023Article
- Repetitive Negative Thinking-Specific and -Nonspecific White Matter Tracts Engaged by Historical Psychosurgical Targets for Depression.Biological psychiatry · 2023Article
- Hyperthymic temperament predicts neural responsiveness for nonmonetary reward.PCN reports : psychiatry and clinical neurosciences · 2023Article
- Resting-state functional alterations in patients with brain arteriovenous malformations involving language areas.Human brain mapping · 2023Article
- Resting state functional connectivity as a marker of internalizing disorder onset in high-risk youth.Scientific reports · 2022Article
- Intrinsic brain abnormalities in female major depressive disorder patients with childhood trauma: A resting-state functional magnetic resonance imaging study.Frontiers in neuroscience · 2022Article
- Neural activity changes in first-episode, drug-naïve patients with major depressive disorder after transcutaneous auricular vagus nerve stimulation treatment: A resting-state fMRI study.Frontiers in neuroscience · 2022Article
- Altered Brain Function and Causal Connectivity Induced by Repetitive Transcranial Magnetic Stimulation Treatment for Major Depressive Disorder.Frontiers in neuroscience · 2022Article
- Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study.Brain sciences · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The pervasive and persistent nature of depressive symptoms has made resting-state functional magnetic resonance imaging (rs-fMRI) an appropriate approach for understanding the underlying mechanisms of major depressive disorder. The majority of rs-fMRI research has focused on depression-related alterations in the interregional coordination of brain baseline low frequency oscillations (LFOs). However, alteration of the regional amplitude of LFOs in depression, particularly its clinical, cognitive and network implications, has not been examined comprehensively yet. rs-fMRI amplitudes of low-frequency fluctuation (ALFF/fALFF) mediated by two LFO bands of 0.01-0.08 Hz (LF-ALFF/fALFF) and 0.1-0.25 Hz (HF-ALFF/fALFF) were measured in unmedicated subjects with major depressive disorder (n=20) and a healthy control group (n=25). A novel method of "ALFF-based functional connectivity" analysis was developed to test regional/network interaction abnormalities in depression. Our results revealed abnormal alterations in ALFF for both lower and higher frequency bands of LFOs in regions that participate in affective networks, corticostriatal circuits and motor/somatosensory networks. A strong positive correlation was detected between depressive symptom severity and fALFF in the anterior cingulate cortex. Functional connectivity of the thalamus and postcentral area with altered ALFF were found to be decreased with other interacting regions of their involved networks. Major depressive disorder relates to the alterations of regional properties of intrinsic neural activity with meaningful clinical and cognitive correlations. This study also proposes an integrating regional/network dysfunction in MDD.
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