ArticleNeurobiology of learning and memory2015
Dopamine depletion in either the dorsomedial or dorsolateral striatum impairs egocentric Cincinnati water maze performance while sparing allocentric Morris water maze learning.
Article in Neurobiology of learning and memory, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Challenges and Opportunities in Exploring Non-Motor Symptoms in 6-Hydroxydopamine Models of Parkinson's Disease: A Systematic Review.Journal of neurochemistry · 2025Pooled it
- Effects of whole brain proton irradiation at conventional or ultra-high dose rate (FLASH), in adult male Sprague Dawley rats.Scientific reports · 2025Article
- Sex and estradiol effects in the rodent dorsal striatum.The European journal of neuroscience · 2024Review
- Tests for learning and memory in rodent regulatory studies.Current research in toxicology · 2024Article
- PINK1 knockout rats show premotor cognitive deficits measured through a complex maze.Frontiers in neuroscience · 2024Article
- Latrophilin-3 heterozygous versus homozygous mutations in Sprague Dawley rats: Effects on egocentric and allocentric memory and locomotor activity.Genes, brain, and behavior · 2022Article
- Review of rodent models of attention deficit hyperactivity disorder.Neuroscience and biobehavioral reviews · 2022Review
- Article
- Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats.Current research in toxicology · 2022Article
- Review of Conventional and High Dose Rate Brain Radiation (FLASH): Neurobehavioural, Neurocognitive and Assessment Issues in Rodent Models.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2021Review
- A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats.Neurobiology of disease · 2021Article
- Latrophilin-3 disruption: Effects on brain and behavior.Neuroscience and biobehavioral reviews · 2021Review
- Translating Neurobehavioral Toxicity Across Species From Zebrafish to Rats to Humans: Implications for Risk Assessment.Frontiers in toxicology · 2021Review
- Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects.Scientific reports · 2020Article
- A general model of hippocampal and dorsal striatal learning and decision making.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Interindividual differences in memory system local field potential activity predict behavioral strategy on a dual-solution T-maze.Hippocampus · 2020Article
- Effects of intrastriatal dopamine D1 or D2 antagonists on methamphetamine-induced egocentric and allocentric learning and memory deficits in Sprague-Dawley rats.Psychopharmacology · 2019Article
- Deltamethrin Exposure Daily From Postnatal Day 3-20 in Sprague-Dawley Rats Causes Long-term Cognitive and Behavioral Deficits.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Effects of Preweaning Manganese in Combination with Adult Striatal Dopamine Lesions on Monoamines, BDNF, TrkB, and Cognitive Function in Sprague-Dawley Rats.Neurotoxicity research · 2019Article
- Learning and Memory Effects of Neonatal Methamphetamine Exposure in Sprague-Dawley Rats: Test of the Role of Dopamine Receptors D1 in Mediating the Long-Term Effects.Developmental neuroscience · 2019Article
Corrections and comments
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8 authors at 1 institution in 1 country.
Funding
Abstract
Both egocentric route-based learning and spatial learning, as assessed by the Cincinnati water maze (CWM) and Morris water maze (MWM), respectively, are impaired following an 80% dopamine (DA) loss in the neostriatum after 6-hydroxydopamine (6-OHDA) administration in rats. The dorsolateral striatum (DLS) and the dorsomedial striatum (DMS) are implicated in different navigational learning types, namely the DLS is implicated in egocentric learning while the DMS is implicated in spatial learning. This experiment tested whether selective DA loss through 6-OHDA lesions in the DMS or DLS would impair one or both types of navigation. Both DLS and DMS DA loss significantly impaired route-based CWM learning, without affecting spatial or cued MWM performance. DLS 6-OHDA lesions produced a 75% DA loss in this region, with no changes in other monoamine levels in the DLS or DMS. DMS 6-OHDA lesions produced a 62% DA loss in this region, without affecting other monoamine levels in the DMS or DLS. The results indicate a role for DA in DLS and DMS regions in route-based egocentric but not spatial learning and memory. Spatial learning deficits may require more pervasive monoamine reductions within each region before deficits are exhibited. This is the first study to implicate DLS and DMS DA in route-based egocentric navigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.