ArticleDevelopmental and comparative immunology2015
A family of variable immunoglobulin and lectin domain containing molecules in the snail Biomphalaria glabrata.
Article in Developmental and comparative immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Probing Bacterial Interactions with theToxins · 2025Article
- Unveiling the hemolymphatic miRNome composition of the schistosomiasis vector snailCurrent research in parasitology & vector-borne diseases · 2025Article
- FromFrontiers in immunology · 2025Review
- Functional insights into immunoglobulin superfamily proteins in invertebrate neurobiology and immunity.Frontiers in immunology · 2025Review
- Exploring the genome-wide transcriptomic responses of Bulinus truncatus to Schistosoma haematobium infection: An important host-parasite system involved in the transmission of human urogenital schistosomiasis.Molecular immunology · 2024Article
- Article
- Accelerating snail vector genomics.Infectious diseases of poverty · 2024Article
- Transcriptional profiling of Bulinus globosus provides insights into immune gene families in snails supporting the transmission of urogenital schistosomiasis.Developmental and comparative immunology · 2024Review
- Article
- Exploring the immune interactions between Oncomelania hupensis and Schistosoma japonicum, with a cross-comparison of immunological research progress in other intermediate host snails.Parasites & vectors · 2023Review
- The genome and transcriptome of the snailbioRxiv : the preprint server for biology · 2023Article
- Transcriptomics of mussel transmissible cancer MtrBTN2 suggests accumulation of multiple cancer traits and oncogenic pathways shared among bilaterians.Open biology · 2023Article
- Comparative mucomic analysis of three functionally distinct Cornu aspersum Secretions.Nature communications · 2023Article
- Host-bacteriome transplants of the schistosome snail host Biomphalaria glabrata reflect species-specific associations.FEMS microbiology ecology · 2023Article
- Status Quo and Future Perspectives of Molecular and Genomic Studies on the GenusInternational journal of molecular sciences · 2023Review
- A genome sequence for Biomphalaria pfeifferi, the major vector snail for the human-infecting parasite Schistosoma mansoni.PLoS neglected tropical diseases · 2023Article
- In search of the Aplysia immunome: an in silico study.BMC genomics · 2022Article
- First Insights into the Repertoire of Secretory Lectins in Rotifers.Marine drugs · 2022Article
- Secreted immunoglobulin domain effector molecules of invertebrates and management of gut microbial ecology.Immunogenetics · 2022Review
- Experimental Infection of theMicroorganisms · 2021Article
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Authors and funding
13 authors.
Funding
Abstract
Technical limitations have hindered comprehensive studies of highly variable immune response molecules that are thought to have evolved due to pathogen-mediated selection such as fibrinogen-related proteins (FREPs) from Biomphalaria glabrata. FREPs combine upstream immunoglobulin superfamily (IgSF) domains with a C-terminal fibrinogen-related domain (FreD) and participate in reactions against trematode parasites. From RNAseq data we assembled a de novo reference transcriptome of B. glabrata to investigate the diversity of FREP transcripts. This study increased over two fold the number of bonafide FREP subfamilies and revealed important sequence diversity within FREP12 subfamily. We also report the discovery of related molecules that feature one or two IgSF domains associated with different C-terminal lectin domains, named C-type lectin-related proteins (CREPs) and Galectin-related protein (GREP). Together, the highly similar FREPs, CREPs and GREP were designated VIgL (Variable Immunoglobulin and Lectin domain containing molecules).
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