ArticleGenomics2014
Genome-wide transcriptome analysis of human epidermal melanocytes.
Article in Genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 44 citations in OpenAlex.
- Deciphering the molecular basis of skin color variation through transcriptomics and machine learning.Scientific reports · 2025Article
- Integrative Transcriptomic and Proteomic Profiling Identifies PMEL as a Critical Regulator of Melanogenesis in Rex Rabbits.Animals : an open access journal from MDPI · 2025Article
- Social and genetic diversity in first farmers of central Europe.Nature human behaviour · 2025Article
- Research progress on peptides that inhibit melanin synthesis.Frontiers in pharmacology · 2025Review
- The role of signaling pathways mediated by the GPCRs CysLTR1/2 in melanocyte proliferation and senescence.Science signaling · 2024Review
- NO-induced apoptosis in human melanocytes from lightly and darkly pigmented skin.Postepy dermatologii i alergologii · 2023Article
- TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases.Frontiers in pharmacology · 2023Review
- PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma.Cell communication and signaling : CCS · 2022Article
- Single-Cell RNA Sequencing Reveals Molecular Features of Heterogeneity in the Murine Retinal Pigment Epithelium.International journal of molecular sciences · 2022Article
- Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver.Cell metabolism · 2021Article
- TRPV1: Role in Skin and Skin Diseases and Potential Target for Improving Wound Healing.International journal of molecular sciences · 2021Review
- Distinguishing Tumor and Stromal Sources of MicroRNAs Linked to Metastasis in Cutaneous Melanoma.Translational oncology · 2020Article
- Up- or Downregulation of Melanin Synthesis Using Amino Acids, Peptides, and Their Analogs.Biomedicines · 2020Review
- Emerging Strategies to Protect the Skin from Ultraviolet Rays Using Plant-Derived Materials.Antioxidants (Basel, Switzerland) · 2020Review
- Screening of an Epigenetic Drug Library Identifies 4-((hydroxyamino)carbonyl)-International journal of molecular sciences · 2020Article
- Delineating the role of MITF isoforms in pigmentation and tissue homeostasis.Pigment cell & melanoma research · 2020Article
- Illuminating insights into opsin 3 function in the skin.Advances in biological regulation · 2020Review
- Human Skin Lightening Efficacy of Resveratrol and Its Analogs: From in Vitro Studies to Cosmetic Applications.Antioxidants (Basel, Switzerland) · 2019Review
- Human nonvisual opsin 3 regulates pigmentation of epidermal melanocytes through functional interaction with melanocortin 1 receptor.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Screening and analysis of differentially expressed genes of human melanocytes in skin cells mixed culture.American journal of translational research · 2019Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Because human epidermal melanocytes (HEMs) provide critical protection against skin cancer, sunburn, and photoaging, a genome-wide perspective of gene expression in these cells is vital to understanding human skin physiology. In this study we performed high throughput sequencing of HEMs to obtain a complete data set of transcript sizes, abundances, and splicing. As expected, we found that melanocyte specific genes that function in pigmentation were among the highest expressed genes. We analyzed receptor, ion channel and transcription factor gene families to get a better understanding of the cell signaling pathways used by melanocytes. We also performed a comparative transcriptomic analysis of lightly versus darkly pigmented HEMs and found 16 genes differentially expressed in the two pigmentation phenotypes; of those, only one putative melanosomal transporter (SLC45A2) has known function in pigmentation. In addition, we found 166 transcript isoforms expressed exclusively in one pigmentation phenotype, 17 of which are genes involved in signal transduction. Our melanocyte transcriptome study provides a comprehensive view and may help identify novel pigmentation genes and potential pharmacological targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.