Evidence map›Paper›PMID 25451168›Full record

ReviewJournal of molecular and cellular cardiology2015

Mitochondrial protein turnover: methods to measure turnover rates on a large scale.

X'avia C Y Chan, Caitlin M Black, Amanda J Lin, Peipei Ping, Edward Lau

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of molecular and cellular cardiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  7. Retrograde Mitochondrial Transport Is Essential for Organelle Distribution and Health in Zebrafish Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
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  14. The Role of Mitochondrial Stress in Muscle Wasting Following Severe Burn Trauma.Journal of burn care & research : official publication of the American Burn Association · 2018
    Review
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

X'avia C Y ChanThe NHLBI Proteomics Center at UCLA, Los Angeles, CA 90095, USA; Department of Physiology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Caitlin M BlackThe NHLBI Proteomics Center at UCLA, Los Angeles, CA 90095, USA; Department of Physiology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Amanda J LinThe NHLBI Proteomics Center at UCLA, Los Angeles, CA 90095, USA; Department of Physiology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Peipei PingThe NHLBI Proteomics Center at UCLA, Los Angeles, CA 90095, USA; Department of Physiology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA; Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA; Department of Bioinformatics, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA. Electronic address: pping@mednet.ucla.edu.
Edward LauThe NHLBI Proteomics Center at UCLA, Los Angeles, CA 90095, USA; Department of Physiology, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA. Electronic address: edwardlau@ucla.edu.
National Institutes of Health · USUniversity of California, Los Angeles · US

Funding

PKC epsilon and Src PTK Signaling in PreconditioningR37HL063901 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PING, PEIPEI · 2010 to 2016
$2.7M
Training in Molecular, Cellular &Integrative PhysiologyT32GM065823 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TIDBALL, JAMES G · 2003 to 2017
$2.1M
NHLBI NIH HHS HHSN268201000035CNHLBI NIH HHS HL-R37-63901NHLBI NIH HHS R37 HL063901NIGMS NIH HHS T32 GM065823
6 · The paper itself

Abstract

Mitochondrial proteins carry out diverse cellular functions including ATP synthesis, ion homeostasis, cell death signaling, and fatty acid metabolism and biogenesis. Compromised mitochondrial quality control is implicated in various human disorders including cardiac diseases. Recently it has emerged that mitochondrial protein turnover can serve as an informative cellular parameter to characterize mitochondrial quality and uncover disease mechanisms. The turnover rate of a mitochondrial protein reflects its homeostasis and dynamics under the quality control systems acting on mitochondria at a particular cell state. This review article summarizes some recent advances and outstanding challenges for measuring the turnover rates of mitochondrial proteins in health and disease. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease".

Indexed as

ProteomeProteomicsAnimalsHumansMitochondriaMitochondrial ProteinsMitochondrial ProteinsProteomeHeavy waterMitochondriaProtein turnoverProteome dynamicsProteomics

Identifiers

PMID25451168
PMCPMC4746024
OpenAlexW2069046026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.