ArticleBrain research2014
Glutamate, GABA, and glutamine are synchronously upregulated in the mouse lateral septum during the postpartum period.
Article in Brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Maternal brain alterations based on neurotransmitter and hormone receptor distributions over six months postpartum.Translational psychiatry · 2026Article
- Causal Links Between Cerebrospinal Fluid Metabolites and Postpartum Depression: A Bidirectional Mendelian Randomization Study.International journal of women's health · 2025Article
- Causal Relationship Between Migraine and Postpartum Depression: A Two-Sample Bidirectional Mendelian Randomization Study.Journal of pain research · 2025Article
- Microbiome Dysbiosis Shows Strong Association of Gut-Derived Altered Metabolomic Profile in Gulf War Chronic Multisymptom Illness Symptom Persistence Following Western Diet Feeding and Development of Obesity.International journal of molecular sciences · 2023Article
- A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior.BMC genomics · 2022Article
- Experience-Regulated Neuronal Signaling in Maternal Behavior.Frontiers in molecular neuroscience · 2022Review
- Survey of neurotransmitter receptor gene expression into and out of parental care in the burying beetleEcology and evolution · 2021Article
- Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.Psychoneuroendocrinology · 2020Article
- The effects of Topiramate on isolation-induced aggression: a behavioral and immunohistochemical study in mice.Psychopharmacology · 2020Article
- Endogenous opioids facilitate intrinsically-rewarded birdsong.Scientific reports · 2020Article
- Pharmacotherapy of Postpartum Depression: Current Approaches and Novel Drug Development.CNS drugs · 2019Review
- Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic resonance imaging and spectroscopy study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- Antidepressant-like effects of translocator protein (18 kDa) ligand ZBD-2 in mouse models of postpartum depression.Molecular brain · 2018Article
- Metabolic Changes Associated with a Rat Model of Diabetic Depression Detected by Ex VivoNeural plasticity · 2018Article
- Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.Psychoneuroendocrinology · 2016Article
- Genetic and neuroendocrine regulation of the postpartum brain.Frontiers in neuroendocrinology · 2016Review
- Metabonomic profiles delineate potential role of glutamate-glutamine cycle in db/db mice with diabetes-associated cognitive decline.Molecular brain · 2016Article
- MicroRNA expression is altered in lateral septum across reproductive stages.Neuroscience · 2016Article
- Metabotropic glutamate receptor 3 is downregulated and its expression is shifted from neurons to astrocytes in the mouse lateral septum during the postpartum period.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Dramatic structural and functional remodeling occurs in the postpartum brain for the establishment of maternal care, which is essential for the growth and development of young offspring. Glutamate and GABA signaling are critically important in modulating multiple behavioral performances. Large scale signaling changes occur in the postpartum brain, but it is still not clear to what extent the neurotransmitters glutamate and GABA change and whether the ratio of glutamate/GABA remains balanced. In this study, we examined the glutamate/GABA-glutamine cycle in the lateral septum (LS) of postpartum female mice. In postpartum females (relative to virgins), tissue levels of glutamate and GABA were elevated in LS and increased mRNA was found for the respective enzymes producing glutamate and GABA, glutaminase (Gls) and glutamate decarboxylase 1 and 2 (Gad1 and Gad2). The common precursor, glutamine, was elevated as was the enzyme that produces it, glutamate-ammonia ligase (Glul). Additionally, glutamate, GABA, and glutamine were positively correlated and the glutamate/GABA ratio was almost identical in the postpartum and virgin females. Collectively, these findings indicate that glutamate and GABA signaling are increased and that the ratio of glutamate/GABA is well balanced in the maternal LS. The postpartum brain may provide a useful model system for understanding how glutamate and GABA are linked despite large signaling changes. Given that some mental health disorders, including depression and schizophrenia display dysregulated glutamate/GABA ratio, and there is increased vulnerability to mental disorders in mothers, it is possible that these postpartum disorders emerge when glutamate and GABA changes are not properly coordinated.
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