ArticleJournal of molecular biology2015
Crosstalk between signaling pathways provided by single and multiple protein phosphorylation sites.
Article in Journal of molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Inflammatory bone loss and signaling pathways in periodontitis: mechanistic insights and emerging therapeutic strategies.Bone research · 2026Review
- Kinase signaling cascades: an updated mechanistic landscape.Chemical science · 2025Review
- Conjoint analysis of succinylome and phosphorylome reveals imbalanced HDAC phosphorylation-driven succinylayion dynamic contibutes to lung cancer.Briefings in bioinformatics · 2024Article
- Large-scale phosphoproteome analysis in wheat seedling leaves provides evidence for extensive phosphorylation of regulatory proteins during CWMV infection.BMC plant biology · 2023Article
- Functional characterization of co-phosphorylation networks.Bioinformatics (Oxford, England) · 2022Article
- Optical chemosensors for the detection of proximally phosphorylated peptides and proteins.RSC chemical biology · 2021Review
- Histone tails as signaling antennas of chromatin.Current opinion in structural biology · 2021Review
- Large-scale Proteomic and Phosphoproteomic Analyses of Maize Seedling Leaves During De-etiolation.Genomics, proteomics & bioinformatics · 2020Article
- Profiling Cell Signaling Networks at Single-cell Resolution.Molecular & cellular proteomics : MCP · 2020Review
- An Integrative Analysis of Tumor Proteomic and Phosphoproteomic Profiles to Examine the Relationships Between Kinase Activity and Phosphorylation.Molecular & cellular proteomics : MCP · 2019Article
- Quantitative Measurement of Functional Activity of the PI3K Signaling Pathway in Cancer.Cancers · 2019Article
- Temperature-induced changes in the wheat phosphoproteome reveal temperature-regulated interconversion of phosphoforms.Journal of experimental botany · 2018Article
- Comparative qualitative phosphoproteomics analysis identifies shared phosphorylation motifs and associated biological processes in evolutionary divergent plants.Journal of proteomics · 2018Article
- Modeling evolution of crosstalk in noisy signal transduction networks.Physical review. E · 2018Article
- Proteins and Proteoforms: New Separation Challenges.Analytical chemistry · 2018Review
- The utility of stem cells in pediatric urinary bladder regeneration.Pediatric research · 2018Review
- Co-occurring protein phosphorylation are functionally associated.PLoS computational biology · 2017Article
- Quantitative phosphoproteomic analysis of early seed development in rice (Oryza sativa L.).Plant molecular biology · 2016Article
- The Transcription Factor Bach2 Is Phosphorylated at Multiple Sites in Murine B Cells but a Single Site Prevents Its Nuclear Localization.The Journal of biological chemistry · 2016Article
- Coupling between Histone Conformations and DNA Geometry in Nucleosomes on a Microsecond Timescale: Atomistic Insights into Nucleosome Functions.Journal of molecular biology · 2016Article
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Authors and funding
3 authors.
Funding
Abstract
Cellular fate depends on the spatiotemporal separation and integration of signaling processes that can be provided by phosphorylation events. In this study, we identify the crucial points in signaling crosstalk that can be triggered by discrete phosphorylation events on a single target protein. We integrated the data on individual human phosphosites with the evidence on their corresponding kinases, the functional consequences of phosphorylation on activity of the target protein and corresponding pathways. Our results show that there is a substantial fraction of phosphosites that can play critical roles in crosstalk between alternative and redundant pathways and regulatory outcome of phosphorylation can be linked to a type of phosphorylated residue. These regulatory phosphosites can serve as hubs in the signal flow and their functional roles are directly connected to their specific properties. Namely, phosphosites with similar regulatory functions are phosphorylated by the same kinases and participate in regulation of similar biochemical pathways. Such sites are more likely to cluster in sequence and space unlike sites with antagonistic outcomes of their phosphorylation on a target protein. In addition, we found that in silico phosphorylation of sites with similar functional consequences has comparable outcomes on a target protein stability. An important role of phosphorylation sites in biological crosstalk is evident from the analysis of their evolutionary conservation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.