ArticleApoptosis : an international journal on programmed cell death2015
An updated view on the structure and function of PYRIN domains.
Article in Apoptosis : an international journal on programmed cell death, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Structural and dynamic basis of NOD2 tandem CARD association and NOD1/2-RIP2 signaling complexes.PLoS computational biology · 2026Article
- Mitochondria affect antibacterial immunity in cross talk with innate immune response molecules coded by genes of nuclear origin.Frontiers in immunology · 2026Article
- Article
- IFI16 recruits HDAC1 and HDAC2 to deacetylate the Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA), facilitating latency.Journal of virology · 2025Article
- Implication of the LRR Domain in the Regulation and Activation of the NLRP3 Inflammasome.Cells · 2024Review
- Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits.EMBO molecular medicine · 2024Review
- Nanoscale organization of the endogenous ASC speck.iScience · 2023Article
- Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities.Frontiers in immunology · 2023Review
- POP1 inhibits MSU-induced inflammasome activation and ameliorates gout.Frontiers in immunology · 2022Article
- Article
- Tissue-selective alternate promoters guide NLRP6 expression.Life science alliance · 2021Article
- An overview of the non-canonical inflammasome.Molecular aspects of medicine · 2020Review
- An Update on CARD Only Proteins (COPs) and PYD Only Proteins (POPs) as Inflammasome Regulators.International journal of molecular sciences · 2020Review
- Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells.PLoS pathogens · 2020Article
- Comprehensive review of ASC structure and function in immune homeostasis and disease.Molecular biology reports · 2020Review
- The Role of Neuronal NLRP1 Inflammasome in Alzheimer's Disease: Bringing Neurons into the Neuroinflammation Game.Molecular neurobiology · 2019Review
- Structure, interactions and self-assembly of ASC-dependent inflammasomes.Archives of biochemistry and biophysics · 2019Review
- The inflammasome adapter ASC assembles into filaments with integral participation of its two Death Domains, PYD and CARD.The Journal of biological chemistry · 2019Article
- COPs and POPs Patrol Inflammasome Activation.Journal of molecular biology · 2018Review
- The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation.Nature communications · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The PYRIN domain (PYD) is a protein-protein interaction domain, which belongs to the death domain fold (DDF) superfamily. It is best known for its signaling function in innate immune responses and particularly in the assembly of inflammasomes, which are large protein complexes that allow the induced proximity-mediated activation of caspase-1 and subsequently the release of pro-inflammatory cytokines. The molecular mechanism of inflammasome assembly was only recently elucidated and specifically requires PYD oligomerization. Here we discuss the recent advances in our understanding of PYD signaling and its regulation by PYD-only proteins.
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