ArticleAmerican journal of human genetics1989
Distal deletion of chromosome Ip in ductal carcinoma of the breast.
Article in American journal of human genetics, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 135 citations in OpenAlex.
- Spatial Chromatin Accessibility Analysis of Intratumor Heterogeneity in Breast Cancer.Genomics, proteomics & bioinformatics · 2026Article
- A novel role for 14-3-3sigma in regulating epithelial cell polarity.Genes & development · 2010Article
- miR-34a repression of SIRT1 regulates apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The role of microsatellite instability at chromosome 11p15.5 in the progression of breast ductal carcinoma.Journal of Korean medical science · 2004Article
- Preferential loss of a polymorphic RIZ allele in human hepatocellular carcinoma.British journal of cancer · 2001Article
- High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Identification of high-risk breast cancer patients from genetic changes of their tumors.Surgery today · 2000Article
- Nonrandom cytogenetic alterations in hepatocellular carcinoma from transgenic mice overexpressing c-Myc and transforming growth factor-alpha in the liver.The American journal of pathology · 1999Article
- Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system.Molecular pathology : MP · 1997Article
- Detection of numerical and structural alterations and fusion of chromosomes 16 and 1 in low-grade papillary breast carcinoma by fluorescence in situ hybridization.The American journal of pathology · 1997Article
- Relation between deletion of chromosome 1p36 and DNA ploidy in breast carcinoma: an interphase cytogenetic study.Clinical molecular pathology · 1996Article
- Genetic analysis of breast cancer progression.Journal of mammary gland biology and neoplasia · 1996Review
- Cytogenetic abnormalities in an in situ ductal carcinoma and five prophylactically removed breasts from members of a family with hereditary breast cancer.Breast cancer research and treatment · 1996Article
- Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations.British journal of cancer · 1995Article
- Familial breast cancer and genes involved in breast carcinogenesis.Breast cancer research and treatment · 1995Review
- LAR tyrosine phosphatase receptor: alternative splicing is preferential to the nervous system, coordinated with cell growth and generates novel isoforms containing extensive CAG repeats.The Journal of cell biology · 1995Article
- The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices.The Biochemical journal · 1994Review
- Identification of a cell-surface glycoprotein associated with normal mammary and extramammary epithelial cells.British journal of cancer · 1994Article
- Tumor suppressor genes and their roles in breast cancer.Breast cancer research and treatment · 1994Review
- Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features.British journal of cancer · 1992Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
By use of recombinant DNA probes that correspond to genetic loci residing on human chromosome 1, DNA samples from 37 ductal breast carcinomas and constitutional DNA from the same individuals were tested for loss of heterozygosity. A high frequency (41%) of reduction to homozygosity was detected with the probe p1-79, which recognizes the highly polymorphic locus D1Z2, localized on 1p36. Loss of heterozygosity at other chromosome 1 loci was much less common, not exceeding a frequency of 10%, and was never observed in the absence of the D1Z2 loss. Somatic loss of heterozygosity at D1Z2 was more frequent in patients with a strong family history of breast cancer (60%), in patients with early diagnosis (before 45 years of age) (70%), and in those with multiple tumors or tumor foci (50%) than in patients with none of the characteristics of hereditary tumors (21%). No associations were observed between loss of heterozygosity and prognostic factors. These results suggest that inactivation of a tumor suppressor gene located on the distal portion of chromosome 1p, alone or combined with other genetic changes, may represent a fundamental step in the pathogenesis of ductal carcinoma of the breast.
Indexed as
Identifiers
2545098PMC1683390W189695663What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.