ArticleOsteoarthritis and cartilage2015
Association between body mass index and risk of total knee replacement, the Singapore Chinese Health Study.
Article in Osteoarthritis and cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Diabetes mellitus is not a risk factor for osteoarthritis.RMD open · 2020Pooled it
- Gene-diet interaction effects on BMI levels in the Singapore Chinese population.Nutrition journal · 2018Pooled it
- Article
- The influence of pain catastrophizing on pain and function after knee arthroplasty in knee osteoarthritis.Scientific reports · 2024Article
- Assessing the health and economic burden of obesity-related complications in East-Asian populations: implementation of risk equations in the Core Obesity Model for Japan and model validation.BMJ public health · 2024Article
- Association of adipokines with severity of knee osteoarthritis assessed clinically and on magnetic resonance imaging.Osteoarthritis and cartilage open · 2023Article
- Validation and interval scale transformation of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in patients undergoing knee arthroplasty, using the Rasch model.Osteoarthritis and cartilage open · 2022Article
- Obesity is associated with an increased risk of undergoing knee replacement in Australia.ANZ journal of surgery · 2022Article
- Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis.JBMR plus · 2022Article
- Food sources of dietary fibre and risk of total knee replacement related to severe osteoarthritis, the Singapore Chinese Health Study.RMD open · 2021Article
- Western-designed total knee implants mismatch Saudi patient knees. Anatomical bony measurements documented by computed tomography.Saudi medical journal · 2020Article
- The association of plasma IL-1Ra and related cytokines with radiographic severity of early knee osteoarthritis.Osteoarthritis and cartilage open · 2020Article
- Reproductive factors and risk of total knee replacement due to severe knee osteoarthritis in women, the Singapore Chinese Health Study.Osteoarthritis and cartilage · 2019Article
- Does the body mass index influence the long-term survival of unicompartmental knee prostheses? A retrospective multi-centre study.International orthopaedics · 2019Article
- Article
- Gout and risk of knee replacement for severe knee osteoarthritis in the Singapore Chinese Health Study.Osteoarthritis and cartilage · 2017Article
- Diabetes mellitus and the risk of total knee replacement among Chinese in Singapore, the Singapore Chinese Health Study.Scientific reports · 2017Article
- Exploring the Link between Uric Acid and Osteoarthritis.Frontiers in medicine · 2017Review
- A Numerical Investigation into the Effects of Overweight and Obesity on Total Knee Arthroplasty.Journal of healthcare engineering · 2017Article
- State of the evidence.Current opinion in rheumatology · 2015Review
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7 authors at 6 institutions in 2 countries.
Funding
Abstract
purposeData on the association between body mass index (BMI) and risk of knee osteoarthritis (KOA) are sparse for Asian populations who are leaner than Western populations. We evaluated the association between BMI and risk of total knee replacement (TKR) due to severe KOA among Chinese in Singapore.
methodsWe used data from the Singapore Chinese Health Study (SCHS), a population-based prospective cohort of 63,257 Chinese men and women, aged 45-74 years at enrollment from 1993 to 1998. Information on height, weight, diet and lifestyle factors were obtained via in-person interviews. TKR cases for severe KOA were identified via linkage with the nationwide hospital discharge database through 2011. Cox regression and weighted least squares regression were used in the analysis.
resultsThe mean BMI among cohort participants was 23.1 kg/m(2), and more than two-thirds had BMI below 25 kg/m(2). A total of 1649 had TKR attributable to severe KOA. Risk of TKR increased in a strong dose-dependent manner with increasing BMI throughout the 15-32 kg/m(2) range and became less clear at BMI >32 kg/m(2). In the BMI range 16-27 kg/m(2), there was a 27% increase in TKR risk for each unit increase in BMI (P for trend < 0.001). Compared to BMI 19-20 kg/m(2), the risk estimates of TKR were all statistically significant with increasing unit of BMI ≥21 kg/m(2). Results were similar for men and women.
conclusionOur results provided evidence for a constant mechanical mechanism underlying BMI and KOA initiation and/or progression.
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