Evidence map›Paper›PMID 25450847›Full record

Trial reportOsteoarthritis and cartilage2015

Effects of total and regional fat loss on plasma CRP and IL-6 in overweight and obese, older adults with knee osteoarthritis.

K M Beavers, D P Beavers, J J Newman, A M Anderson, R F Loeser, B J Nicklas, M F Lyles, G D Miller, S L Mihalko, S P Messier

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Osteoarthritis and cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00381290 (Intensive Diet and Exercise for Arthritis), which is not on this map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00381290 nacompletednot on this map

Intensive Diet and Exercise for Arthritis

TypeinterventionalSponsorWake Forest UniversityRan2006 to 2011Enrolled454ConditionsOsteoarthritisArmsDiet, Exercise
3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.

  1. Exercise for osteoarthritis of the knee.The Cochrane database of systematic reviews · 2024
    Pooled it
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  8. Effect of Intentional Weight Loss on Mortality Biomarkers in Older Adults With Obesity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019
    Trial
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  13. Article
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  16. Article
  17. Review
  18. Role of C-Reactive Protein, An Inflammatory Biomarker in The Development of Atherosclerosis and Its Treatment.The International journal of angiology : official publication of the International College of Angiology, Inc · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

K M BeaversDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA. Electronic address: beaverkm@wfu.edu.
D P BeaversDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: dbeavers@wakehealth.edu.
J J NewmanDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA. Electronic address: jollajk@wfu.edu.
A M AndersonDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: amanders@wakehealth.edu.
R F LoeserDivision of Rheumatology, Allergy, and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, USA. Electronic address: richard_loeser@med.unc.edu.
B J NicklasSection on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: bnicklas@wakehealth.edu.
M F LylesSection on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: mlyles@wakehealth.edu.
G D MillerDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA. Electronic address: millergd@wfu.edu.
S L MihalkoDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA. Electronic address: mihalksl@wfu.edu.
S P MessierDepartment of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, USA. Electronic address: messier@wfu.edu.
Wake Forest University · USUniversity of North Carolina at Chapel Hill · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Intensive Dietary Restriction with Exercise in ArthritisR01AR052528 · NIAMS · WAKE FOREST UNIVERSITY · PI MESSIER, STEPHEN P · 2006 to 2010
$2.9M
NIAMS NIH HHS AR052528NIAMS NIH HHS R01 AR052528NIA NIH HHS P30 AG021332NIA NIH HHS P30-AG21332
6 · The paper itself

Abstract

objectiveTo describe associations between total and regional body fat mass loss and reduction of systemic levels of inflammation (C-reactive protein (CRP) and interleukin-6 (IL-6)) in obese, older adults with osteoarthritis (OA), undergoing intentional weight loss.

designData come from a single-blind, 18-month, randomized controlled trial in adults (age: 65.6 ± 6.2; Body mass index (BMI): 33.6 ± 3.7) with knee OA. Participants were randomized to diet-induced weight loss plus exercise (D + E; n = 150), diet-induced weight loss-only (D; n = 149), or exercise-only (E; n = 151). Total body and region-specific (abdomen and thigh) fat mass were measured at baseline and 18 months. High-sensitivity CRP and IL-6 were measured at baseline, six and 18 months. Intervention effects were assessed using mixed models and associations between inflammation and adiposity were compared using logistic and mixed linear regression models.

resultsIntentional total body fat mass reduction was associated with significant reductions in log-adjusted CRP (β = 0.06 (95% CI = 0.04, 0.08) mg/L) and IL-6 (β = 0.02 (95% CI = 0.01, 0.04) pg/mL). Loss of abdominal fat volume was also associated with reduced inflammation, independent of total body fat mass; although models containing measures of total adiposity yielded the best fit. The odds of achieving clinically desirable levels of CRP (<3.0 mg/L) and IL-6 (<2.5 pg/mL) were 3.8 (95% CI = 1.6, 8.9) and 2.2 (95% CI = 1.1, 4.6), respectively, with 5% total weight and fat mass loss.

conclusionsAchievement of clinically desirable levels of CRP and IL-6 more than double with intentional 5% loss of total body weight and fat mass. Global, rather than regional, measures of adiposity are better predictors of change in inflammatory burden. CLINICAL TRIAL REGISTRATION NUMBER: NCT00381290.

Indexed as

AgedC-Reactive ProteinDiet, ReducingExerciseFemaleHumansInterleukin-6MaleObesityOsteoarthritis, KneeOverweightSingle-Blind MethodWeight LossC-Reactive ProteinInterleukin-6InflammationOsteoarthritisRegional fat massTotal body fat massWeight loss

Identifiers

PMID25450847
PMCPMC4304884
OpenAlexW2004696945

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.