Evidence map›Paper›PMID 25450327›Full record

ReviewFree radical biology & medicine2015

Collaboration between mitochondria and the nucleus is key to long life in Caenorhabditis elegans.

Hsin-Wen Chang, Ludmila Shtessel, Siu Sylvia Lee

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Free radical biology & medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Aging Epigenome.Molecular cell · 2016
    Review
  8. The metabolic regulation of aging.Nature medicine · 2015
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hsin-Wen ChangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
Ludmila ShtesselDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA.
Siu Sylvia LeeDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA. Electronic address: sylvia.lee@cornell.edu.

Funding

Systematic Analysis of C elegans Longevity DeterminantsR01AG024425 · NIA · CORNELL UNIVERSITY ITHACA · PI Siu Sylvia Lee · 2004 to 2026
$8.5M
NIA NIH HHS R01 AG024425
6 · The paper itself

Abstract

Recent findings in diverse organisms strongly support a conserved role for mitochondrial electron transport chain dysfunction in longevity modulation, but the underlying mechanisms are not well understood. One way cells cope with mitochondrial dysfunction is through a retrograde transcriptional reprogramming response. In this review, we primarily focus on the work that has been performed in Caenorhabditis elegans to elucidate these mechanisms. We describe several transcription factors that participate in mitochondria-to-nucleus signaling and discuss how they mediate the relationship between mitochondrial dysfunction and life span.

Indexed as

LongevityAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell NucleusMitochondriaSignal TransductionTranscription FactorsCaenorhabditis elegans ProteinsTranscription FactorsAgingFree radicalsLongevityMitochondrial electron transport chainRetrograde signalingTranscription factors

Identifiers

PMID25450327
PMCPMC4280335

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.