SynthesisSleep & breathing = Schlaf & Atmung2015
Beneficial effect of continuous positive airway pressure on lipid profiles in obstructive sleep apnea: a meta-analysis.
Synthesis in Sleep & breathing = Schlaf & Atmung, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Effect of sleep surgery on lipid profiles in adults with obstructive sleep apnea: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Pooled it
- Continuous positive airway pressure can improve depression in patients with obstructive sleep apnoea syndrome: a meta-analysis based on randomized controlled trials.The Journal of international medical research · 2020Pooled it
- Meta-analysis of all-cause and cardiovascular mortality in obstructive sleep apnea with or without continuous positive airway pressure treatment.Sleep & breathing = Schlaf & Atmung · 2017Pooled it
- Effect of continuous positive airway pressure on blood pressure and metabolic profile in women with sleep apnoea.The European respiratory journal · 2017Trial
- Chronicity and comorbidities: Is estimated longer duration of obstructive sleep apnoea linked to higher cardiometabolic risk?Lung India : official organ of Indian Chest Society · 2026Article
- The association between serum uric acid and homocysteine is mediated by metabolic risk factors.Scientific reports · 2025Article
- The effect of PAP on UACR and metabolic indexes in patients with MS and OSAHS.Sleep & breathing = Schlaf & Atmung · 2024Article
- Gas exchange parameters for the prediction of obstructive sleep apnea in infants.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development.Nature communications · 2024Article
- The association of nocturnal hypoxemia with dyslipidemia in sleep-disordered breathing population of Chinese community: a cross-sectional study.Lipids in health and disease · 2023Article
- The association between biomarker angiopoietin-like protein five and obstructive sleep apnea in patients undergoing bariatric surgery.Sleep & breathing = Schlaf & Atmung · 2023Article
- Management of non-alcoholic fatty liver disease patients with sleep apnea syndrome.World journal of gastroenterology · 2022Review
- Obstructive Sleep Apnoea and Lipid Metabolism: The Summary of Evidence and Future Perspectives in the Pathophysiology of OSA-Associated Dyslipidaemia.Biomedicines · 2022Review
- ANGPTL3 and Cardiovascular Outcomes in Patients With Acute Coronary Syndrome and Obstructive Sleep Apnea.Journal of the American Heart Association · 2022Article
- Effect of Continuous Positive Airway Pressure on Lipid Profiles in Obstructive Sleep Apnea: A Meta-Analysis.Journal of clinical medicine · 2022Article
- CPAP Intervention as an Add-On Treatment to Lipid-Lowering Medication in Coronary Artery Disease Patients with Obstructive Sleep Apnea in the RICCADSA Trial.Journal of clinical medicine · 2022Article
- Prediction of Mandibular Advancement Device Response Using CPAP Pressure in Different Polysomnographic Phenotypes.Nature and science of sleep · 2022Article
- A Prospective Study of CPAP Therapy in Relation to Cardiovascular Outcome in a Cohort of Romanian Obstructive Sleep Apnea Patients.Journal of personalized medicine · 2021Article
- [Changes of carotid artery elasticity before and after CPAP in patients with obstructive sleep apnea by ultrasonic ultrafast pulse wave velocity technique].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Article
- Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients after Multilevel Sleep Surgery.Metabolites · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDyslipidemia is considered as one mechanism causing cardiovascular sequelae in obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) can reduce cardiovascular morbidities but its effect on lipid profiles is inconclusive. This study aimed to investigate the effects of CPAP on lipid profiles by a meta-analysis of the existing randomized controlled trials.
methodsStudies were retrieved from MEDLINE/PubMed, EMBASE, CENTRAL, commercial websites, and article references up to August 2013 following the protocols (PROSPERO CRD42012002636). Randomized controlled trials investigating the CPAP effects on changes in lipid profiles in adult patients with OSA were included. Two independent researchers extracted relevant data in duplicate. The pooled effect was analyzed by fixed-effect generic inverse variance, and the heterogeneity was assessed using the I (2) statistic.
resultsSix trials with 348 patients and 351 controls were included. CPAP significantly lowered total cholesterol (mean, -6.23 mg/dl; 95% CI, -8.73 to -3.73; I (2), 0%; p < 0.001), triglyceride (mean, -12.60 mg/dl; 95% CI, -18.80 to -6.41; I (2), 25%; p < 0.001), and high-density lipoprotein (mean, -1.05 mg/dl; 95% CI, -1.69 to -0.40; I (2), 0%; p = 0.001), but not low-density lipoprotein (mean, -1.01 mg/dl; 95% CI, -5.04 to 3.02; I (2), 0%; p = 0.62). The lipid-lowering effects were homogeneous across the studies. By subgroup analysis, the reductions of lipid profiles were associated with the cross-over design, subtherapeutic CPAP as placebo, enrolled patients with moderate-to-severe OSA or daytime sleepiness, and CPAP treatment with short-term duration or good compliance.
conclusionsThis meta-analysis validates the observation that CPAP can reduce lipid profiles in patients with OSA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.