ArticleExperimental eye research2015
The rat retina has five types of ganglion-cell photoreceptors.
Article in Experimental eye research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 64 citations in OpenAlex.
- Gap junctions fine-tune ganglion cell signals to equalize response kinetics within a given electrically coupled array.iScience · 2024Article
- A Comprehensive Overview of the Neural Mechanisms of Light Therapy.Neuroscience bulletin · 2024Review
- Small-molecule-driven direct reprogramming of Müller cells into bipolar-like cells.Cell proliferation · 2022Article
- Exposure to Blue Light Reduces Melanopsin Expression in Intrinsically Photoreceptive Retinal Ganglion Cells and Damages the Inner Retina in Rats.Investigative ophthalmology & visual science · 2022Article
- Subtype-specific survival and regeneration of retinal ganglion cells in response to injury.Frontiers in cell and developmental biology · 2022Review
- 7,8-Dihydroxiflavone Maintains Retinal Functionality and Protects Various Types of RGCs in Adult Rats with Optic Nerve Transection.International journal of molecular sciences · 2021Article
- Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions.Cellular and molecular life sciences : CMLS · 2021Review
- Comparative Neurology of Circadian Photoreception: The Retinohypothalamic Tract (RHT) in Sighted and Naturally Blind Mammals.Frontiers in neuroscience · 2021Review
- Effects of achromatic and chromatic lights on pupillary response, endocrinology, activity, and milk production in dairy cows.PloS one · 2021Article
- Intrinsically Photosensitive Retinal Ganglion Cells of the Human Retina.Frontiers in neurology · 2021Review
- Crosstalk: The diversity of melanopsin ganglion cell types has begun to challenge the canonical divide between image-forming and non-image-forming vision.The Journal of comparative neurology · 2020Review
- Circadian Photoentrainment in Mice and Humans.Biology · 2020Review
- Metabolic Effects of Light at Night are Time- and Wavelength-Dependent in Rats.Obesity (Silver Spring, Md.) · 2020Article
- Overlapping morphological and functional properties between M4 and M5 intrinsically photosensitive retinal ganglion cells.The Journal of comparative neurology · 2020Article
- Light entrainment of retinal biorhythms: cryptochrome 2 as candidate photoreceptor in mammals.Cellular and molecular life sciences : CMLS · 2020Article
- Local photoreceptor degeneration causes local pathophysiological remodeling of retinal neurons.JCI insight · 2020Article
- Neuronal Responses to Short Wavelength Light Deficiency in the Rat Subcortical Visual System.Frontiers in neuroscience · 2020Article
- Blue light at night acutely impairs glucose tolerance and increases sugar intake in the diurnal rodent Arvicanthis ansorgei in a sex-dependent manner.Physiological reports · 2019Article
- Photosensitive Melanopsin-Containing Retinal Ganglion Cells in Health and Disease: Implications for Circadian Rhythms.International journal of molecular sciences · 2019Review
- MelanopsinInternational journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Intrinsically photosensitive retinal ganglion cells (ipRGCs) are inner retinal photoreceptors that mediate non-image-forming visual functions, e.g. pupillary constriction, regulation of pineal melatonin release, and circadian photoentrainment. Five types of ipRGCs were recently discovered in mouse, but whether they exist in other mammals remained unknown. We report that the rat also has five types of ipRGCs, whose morphologies match those of mouse ipRGCs; this is the first demonstration of all five cell types in a non-mouse species. Through immunostaining and λmax measurements, we showed that melanopsin is likely the photopigment of all rat ipRGCs. The various cell types exhibited diverse spontaneous spike rates, with the M1 type spiking the least and M4 spiking the most, just like we had observed for their mouse counterparts. Also similar to mouse, all ipRGCs in rat generated not only sluggish intrinsic photoresponses but also fast, synaptically driven ones. However, we noticed two significant differences between these species. First, whereas we learned previously that all mouse ipRGCs had equally sustained synaptic light responses, rat M1 cells' synaptic photoresponses were far more transient than those of M2-M5. Since M1 cells provide all input to the circadian clock, this rat-versus-mouse discrepancy could explain the difference in photoentrainment threshold between mouse and other species. Second, rat ipRGCs' melanopsin-based spiking photoresponses could be classified into three varieties, but only two were discerned for mouse ipRGCs. This correlation of spiking photoresponses with cell types will help researchers classify ipRGCs in multielectrode-array (MEA) spike recordings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.