Observational studyEndocrine2015
The associations of bedtime, nocturnal, and daytime sleep duration with bone mineral density in pre- and post-menopausal women.
Observational study in Endocrine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Association Between Sleep Duration and Low Bone Mineral Density and Osteoporosis: A Systematic Review and Meta-analysis.Calcified tissue international · 2024Pooled it
- Sleep duration and the risk of osteoporosis among middle-aged and elderly adults: a dose-response meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- Bone Turnover Markers After Sleep Restriction and Circadian Disruption: A Mechanism for Sleep-Related Bone Loss in Humans.The Journal of clinical endocrinology and metabolism · 2017Trial
- Impact of sleep duration on bone mineral density and osteoporosis risk: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2026Review
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.Current biology : CB · 2026Article
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.bioRxiv : the preprint server for biology · 2025Article
- Association Between Changes in Sleep, Nap Duration and Bone Mineral Density in Mexican Adults.Calcified tissue international · 2024Article
- β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture.Bone research · 2024Article
- Association of nocturnal sleep duration and sleep midpoint with osteoporosis risk in rural adults: a large-scale cross-sectional study.Sleep & breathing = Schlaf & Atmung · 2023Article
- Nocturnal sleep duration and bone mineral density: a cross-sectional study of the National Health and Nutrition Examination Survey (NHANES) 2007-2014.BMC endocrine disorders · 2022Article
- The role of circadian rhythm in osteoporosis; a review.Frontiers in cell and developmental biology · 2022Review
- Relationship between sleep pattern and bone mineral density in patients with osteoporotic fracture.Therapeutic advances in endocrinology and metabolism · 2022Article
- Sleep disruptions and bone health: what do we know so far?Current opinion in endocrinology, diabetes, and obesity · 2021Review
- A cross-sectional analysis of the association between sleep duration and osteoporosis risk in adults using 2005-2010 NHANES.Scientific reports · 2021Article
- Sleep duration and bone health measures in older men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- The associations between different sleep patterns and osteoporosis based on the Osteoporosis Self-Assessment Tool for Asians.Archives of osteoporosis · 2020Article
- Potential Role of Lycopene in the Prevention of Postmenopausal Bone Loss: Evidence from Molecular to Clinical Studies.International journal of molecular sciences · 2020Review
- [Relationship between sleep quality and bone mineral density in urban residents].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020Article
- Bone turnover is altered during 72 h of sleep restriction: a controlled laboratory study.Endocrine · 2019Article
- Relationship between melatonin and bone resorption rhythms in premenopausal women.Journal of bone and mineral metabolism · 2019Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the association of sleep patterns with bone mineral density (BMD) in pre- and post-menopausal women, we used a questionnaire to evaluate the sleep patterns and performed calcaneal quantitative ultrasound to estimate BMD, in 6,510 women aged 40 years or older, from June to November 2011 in Nanjing City. We found a 1.7-fold risk of osteoporosis in post-menopausalwomen with bedtime of ≥0:00 am (OR = 1.69, 95 % CI 1.39-2.13), compared to those whose bedtime of <0:00 am. post-menopausalwomen with excessive total sleep (>10 h vs. 8-9 h, OR = 1.54, 95 % CI 1.05-2.02) were shown to have a higher risk of osteoporosis, however, this high risk was not detected in those with excessive nocturnal sleep (>10 h vs. 8-9 h, OR = 0.85, 95 % CI 0.62-1.30). By contrast, post-menopausalwomen with inadequate nocturnal sleep (≤7 h vs. 8-9 h, OR = 1.68, 95 % CI 1.32-2.75), excessive daytime sleep (≥180 min vs. 0 min, OR = 1.52, 95 % CI 1.08-2.13), and noontime nap (>60 min vs. 0 min: OR = 1.37, 95 % CI 1.06-1.76) were demonstrated to have higher risk of bone loss. Nevertheless, these associations were not found in premenopausal women. We conclude that delayed bedtime, nocturnal sleep deprivation, excessive daytime sleep, and noontime nap, but not reduced total sleep duration, could promote bone loss in post-menopausalwomen, which might be related to circadian rhythm disturbances. However, they have limited influences to BMD in women who were still in menstruating. Mechanism responsible for the phenomena warrants further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.