Evidence map›Paper›PMID 25449935›Full record

ArticleIndian journal of ophthalmology2014

Etiology and clinical profile of childhood optic nerve atrophy at a tertiary eye care center in South India.

Supriya Chinta, Batriti S Wallang, Virender Sachdeva, Amit Gupta, Preeti Patil-Chhablani, Ramesh Kekunnaya

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Article in Indian journal of ophthalmology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Optic nerve and choroidal calcification in pediatric neurofibromatosis type 2.American journal of ophthalmology case reports · 2025
    Article
  3. NovelIndian journal of ophthalmology · 2022
    Article
  4. Screening of blind children - Its importance.Indian journal of ophthalmology · 2022
    Article
  5. Review
  6. Determination of ventriculoperitoneal shunt dysfunction using optic nerve sheath diameter measurement on CT scan in pediatric patients with hydrocephalus.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  7. Manual Acupuncture for Optic Atrophy: A Systematic Review and Meta-Analysis.Evidence-based complementary and alternative medicine : eCAM · 2019
    Review
  8. Article
  9. Author's Reply.Indian journal of ophthalmology · 2015
    Article
  10. Article
  11. Observational
  12. Visual Loss in Biotinidase Deficiency.Annals of Indian Academy of Neurology
    Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Supriya Chinta
Batriti S Wallang
Virender Sachdeva
Amit Gupta
Preeti Patil-Chhablani
Ramesh KekunnayaJasti V Ramanamma Children's Eye Care Center, L V Prasad Eye Institute, KAR Campus, Banjara Hills, Hyderabad, India.
L V Prasad Eye Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOptic nerve atrophy is an important ophthalmological sign that may be associated with serious systemic conditions having a significant bearing on the overall morbidity of the child. Studies specific to etiology of childhood optic atrophy are scarce, this being the first such study from India to the best of our knowledge.

aimThe aim was to analyze the clinical features and etiology of diagnosed cases of optic nerve atrophy in children <16 years of age. MATERIALS AND

methodsRetrospective review of records of children diagnosed with optic nerve atrophy between the ages of 0 and 16 years from 2006 to 2011.

resultsA total of 324 children (583 eyes) were identified. Among these 160 (49%) presented with defective vision, 71 (22%) with strabismus, 18 (6%) with only nystagmus. Rest had a combination of two or three of the above symptoms. Sixty-five patients (20%) had a unilateral affection. Hypoxic ischemic encephalopathy seen in 133 patients (41%) was the most frequent cause of childhood optic atrophy, followed by idiopathic in 98 (30%), hydrocephalus in 24 (7%), compressive etiology in 18 (5%), infective in 19 (6%), congenital in 6 (2%), inflammatory in 5 (2%) patients, respectively.

conclusionHypoxic ischemic encephalopathy appears to be the most common cause of optic atrophy in children in this series. The most common presenting complaint was defective vision.

Indexed as

Tertiary Care CentersAdolescentChildChild, PreschoolElectroretinographyFemaleFollow-Up StudiesHumansHypoxia-Ischemia, BrainIndiaInfantInfant, NewbornMagnetic Resonance ImagingMaleOptic AtrophyOptic Nerve

Identifiers

PMID25449935
PMCPMC4278110
OpenAlexW2021599866

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.