ReviewMicrobes and infection2014
The STING controlled cytosolic-DNA activated innate immune pathway and microbial disease.
Review in Microbes and infection, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Review
- Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway.Nature communications · 2025Article
- STING and cGAS gene expressions were downregulated among HIV-1-infected persons after antiretroviral therapy.Virology journal · 2021Article
- Why is Listeria monocytogenes such a potent inducer of CD8+ T-cells?Cellular microbiology · 2020Review
- Varicella-Zoster Virus and the Enteric Nervous System.The Journal of infectious diseases · 2018Article
- The cGas-Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus.Frontiers in immunology · 2018Article
- Dysregulated cellular functions and cell stress pathways provide critical cues for activating and targeting natural killer cells to transformed and infected cells.Immunological reviews · 2017Review
- The Scaffolding Protein IQGAP1 Interacts with NLRC3 and Inhibits Type I IFN Production.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Immunological Tolerance, Pregnancy, and Preeclampsia: The Roles of Semen Microbes and the Father.Frontiers in medicine · 2017Article
- The Bacterial Second Messenger Cyclic di-GMP Regulates Brucella Pathogenesis and Leads to Altered Host Immune Response.Infection and immunity · 2016Article
- IL-10 Modulates Th17 Pathogenicity during Autoimmune Diseases.Journal of clinical & cellular immunology · 2016Article
- Insights into the role of immunosenescence during varicella zoster virus infection (shingles) in the aging cell model.Oncotarget · 2015Article
- Intracellular detection of viral nucleic acids.Current opinion in microbiology · 2015Review
- Review
- Antibodies Are Required for Complete Vaccine-Induced Protection against Herpes Simplex Virus 2.PloS one · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The innate immune system is critically important for the primary sensing of invading pathogens. Over the past decade, the cellular sensors important for recognizing microbial entry into the host cell have been largely elucidated. These sensors, some of which are evolutionarily conserved, include the Toll-like receptor (TLR) and RIG-I-like helicase family (RLH) pathway that can recognize bacterial and viral non-self nucleic acid. In addition, a cellular sensor referred to as STING (for stimulator of interferon genes) has been shown to be critical for triggering host defense countermeasures, including stimulation of the adaptive immune response, following the detection of cytosolic DNA species. The STING pathway has now been shown to be critical for activating innate immune gene transcription in response to infection by DNA pathogens such as herpes simplex virus 1 (HSV1) as well as retroviruses. In addition, it is clear that chronic STING activation can also cause autoinflammatory disease manifested by self-DNA. Here we review recent developments in our understanding of STING function, including importance in the control of microbial disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.