ArticleNeuroImage2015
Probing region-specific microstructure of human cortical areas using high angular and spatial resolution diffusion MRI.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Considerations and recommendations from the ISMRM diffusion study group for preclinical diffusion MRI: Part 2-Ex vivo imaging: Added value and acquisition.Magnetic resonance in medicine · 2025Guideline
- A map of the human neocortex showing the estimated overall myelin content of the individual architectonic areas based on the studies of Adolf Hopf.Brain structure & function · 2017Pooled it
- No Effect of Anodal tDCS on Verbal Episodic Memory Performance and Neurotransmitter Levels in Young and Elderly Participants.Neural plasticity · 2020Trial
- Advanced microstructure imaging at high b-values and high resolution combining ultra-high performance gradient diffusion imaging and model-based deep learning demonstrated using 3D multi-slab acquisition.Magnetic resonance in medicine · 2026Article
- Analysis of cortical dysplasias using b-tensor encoding diffusion MRI in an animal model.PloS one · 2026Article
- General Microstructure Factor Analysis of Diffusion MRI in Gray-Matter Predicts Cognitive Scores.ArXiv · 2025Article
- 3D MERMAID: 3D Multi-shot enhanced recovery motion artifact insensitive diffusion for submillimeter, multi-shell, and SNR-efficient diffusion imaging.Magnetic resonance in medicine · 2025Article
- Mapping grey and white matter activity in the human brain with isotropic ADC-fMRI.Nature communications · 2025Article
- Layer-Dependent Effect of Aβ-Pathology on Cortical Microstructure With Ex Vivo Human Brain Diffusion MRI at 7 Tesla.Human brain mapping · 2025Article
- Advanced diffusion imaging in grey matter reflects individual differences in cognitive ability in older adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Mild traumatic brain injury increases cortical iron: evidence from individual susceptibility mapping.Brain communications · 2025Article
- A holistic visualization for quality of Chinese materia medica: Structural and metabolic visualization by magnetic resonance imaging.Journal of pharmaceutical analysis · 2024Review
- Spatiotemporal patterns of cortical microstructural maturation in children and adolescents with diffusion MRI.Human brain mapping · 2024Article
- Direct segmentation of cortical cytoarchitectonic domains using ultra-high-resolution whole-brain diffusion MRI.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Article
- Magnetic resonance imaging at 9.4 T: the Maastricht journey.Magma (New York, N.Y.) · 2023Review
- High-fidelity, high-spatial-resolution diffusion magnetic resonance imaging of ex vivo whole human brain at ultra-high gradient strength with structured low-rank echo-planar imaging ghost correction.NMR in biomedicine · 2023Article
- Mapping the individual human cortex using multidimensional MRI and unsupervised learning.Brain communications · 2023Article
- Microstructural mapping of dentate gyrus pathology in Alzheimer's disease: A 16.4 Tesla MRI study.NeuroImage. Clinical · 2023Article
- Diffusion MRI anisotropy in the cerebral cortex is determined by unmyelinated tissue features.Nature communications · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Regional heterogeneity in cortical cyto- and myeloarchitecture forms the structural basis of mapping of cortical areas in the human brain. In this study, we investigate the potential of diffusion MRI to probe the microstructure of cortical gray matter and its region-specific heterogeneity across cortical areas in the fixed human brain. High angular resolution diffusion imaging (HARDI) data at an isotropic resolution of 92-μm and 30 diffusion-encoding directions were acquired using a 3D diffusion-weighted gradient-and-spin-echo sequence, from prefrontal (Brodmann area 9), primary motor (area 4), primary somatosensory (area 3b), and primary visual (area 17) cortical specimens (n=3 each) from three human subjects. Further, the diffusion MR findings in these cortical areas were compared with histological silver impregnation of the same specimens, in order to investigate the underlying architectonic features that constitute the microstructural basis of diffusion-driven contrasts in cortical gray matter. Our data reveal distinct and region-specific diffusion MR contrasts across the studied areas, allowing delineation of intracortical bands of tangential fibers in specific layers-layer I, layer VI, and the inner and outer bands of Baillarger. The findings of this work demonstrate unique sensitivity of diffusion MRI to differentiate region-specific cortical microstructure in the human brain, and will be useful for myeloarchitectonic mapping of cortical areas as well as to achieve an understanding of the basis of diffusion NMR contrasts in cortical gray matter.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.