ArticleNeuroImage2015
Gray matter myelination of 1555 human brains using partial volume corrected MRI images.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed, 171 citations in OpenAlex.
- Methylphenidate Effects on Cortical Thickness in Children and Adults with Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial.AJNR. American journal of neuroradiology · 2020Trial
- Frequency and laminar profile of feature-specific visual activity revealed by interleaved EEG-fMRI.eLife · 2026Article
- Quantitative MRI analysis of deep gray matter aging: Volumetric, T1/T2 ratio, and blood perfusion alterations.Neuroimage. Reports · 2026Article
- The cellular correlates and adolescent reorganisation of cortical myelination networks in the common marmoset.Communications biology · 2026Article
- Cerebral Cortex Morphometry and Relaxometry in Male Children With Fragile X Syndrome and Autism.Brain and behavior · 2026Article
- A DERIVED RELAXATION CONTRAST FROM SYNTHETIC MRI FOR DETECTING NETWORK MICROSTRUCTURAL VULNERABILITY.bioRxiv : the preprint server for biology · 2026Article
- Multiparametric CEST and Z-spectrum analysis proton (ZAP) as biomarkers of human brain aging.Scientific reports · 2026Article
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- The T1-Weighted/T2-Weighted Ratio as an In Vivo Proxy for Reduced Intracortical Myelin Content in Youth With RASopathies: A Cross-Sectional Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Visualizing cortical laminar architecture in the living human brain using next-generation ultra-high-gradient diffusion MRI.Communications biology · 2026Article
- T1w/T2w ratio suggests reduced intracortical myelin content in youth with RASopathies.medRxiv : the preprint server for health sciences · 2025Article
- Humans have a longer period of cortical maturation across depth and hierarchy than macaques.PLoS biology · 2025Article
- Complementary MR measures of white matter and their relation to cardiovascular health and cognition.Scientific reports · 2025Article
- Myelination across cortical hierarchies and depths in humans and macaques.bioRxiv : the preprint server for biology · 2025Article
- Heterochronous laminar maturation in the human prefrontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Human gray matter microstructure mapped using neurite exchange imaging (NEXI) on a clinical scanner.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Casual associations between brain structure and sarcopenia: A large-scale genetic correlation and mendelian randomization study.Aging cell · 2024Article
- Investigating grey matter volumetric trajectories through the lifespan at the individual level.Nature communications · 2024Article
- Associations between atypical intracortical myelin content and neuropsychological functions in middle to older aged adults with ASD.Brain and behavior · 2024Article
- Oxygen and the Spark of Human Brain Evolution: Complex Interactions of Metabolism and Cortical Expansion across Development and Evolution.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The myelin content of the cortex changes over the human lifetime and aberrant cortical myelination is associated with diseases such as schizophrenia and multiple sclerosis. Recently magnetic resonance imaging (MRI) techniques have shown potential in differentiating between myeloarchitectonically distinct cortical regions in vivo. Here we introduce a new algorithm for correcting partial volume effects present in mm-scale MRI images which was used to investigate the myelination pattern of the cerebral cortex in 1555 clinically normal subjects using the ratio of T1-weighted (T1w) and T2-weighted (T2w) MRI images. A significant linear cross-sectional age increase in T1w/T2w estimated myelin was detected across an 18 to 35 year age span (highest value of ~ 1%/year compared to mean T1w/T2w myelin value at 18 years). The cortex was divided at mid-thickness and the value of T1w/T2w myelin calculated for the inner and outer layers separately. The increase in T1w/T2w estimated myelin occurs predominantly in the inner layer for most cortical regions. The ratio of the inner and outer layer T1w/T2w myelin was further validated using high-resolution in vivo MRI scans and also a high-resolution MRI scan of a postmortem brain. Additionally, the relationships between cortical thickness, curvature and T1w/T2w estimated myelin were found to be significant, although the relationships varied across the cortex. We discuss these observations as well as limitations of using the T1w/T2w ratio as an estimate of cortical myelin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.