Evidence map›Paper›PMID 25449559›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2015

Effects of robotic-locomotor training on stretch reflex function and muscular properties in individuals with spinal cord injury.

Mehdi M Mirbagheri, Matthew W Kindig, Xun Niu

Abstract read
In one paragraph

Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Relationship Between Spinal Reflexes and Spastic Movement Disorders.Physical medicine and rehabilitation clinics of North America · 2026
    Review
  7. Application of Artificial Intelligence in Physical Rehabilitation of Patients Admitted to the Intensive Care Unit: A Scoping Review.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Spinal plasticity in robot-mediated therapy for the lower limbs.Journal of neuroengineering and rehabilitation · 2015
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Mehdi M MirbagheriDepartment of Physical Medicine and Rehabilitation, Northwestern University, USA; Sensory Motor Performance Program, Rehabilitation Institute of Chicago, USA. Electronic address: Mehdi@northwestern.edu.
Matthew W KindigSensory Motor Performance Program, Rehabilitation Institute of Chicago, USA.
Xun NiuDepartment of Physical Medicine and Rehabilitation, Northwestern University, USA; Sensory Motor Performance Program, Rehabilitation Institute of Chicago, USA.
Shirley Ryan AbilityLab · USNorthwestern University · US

Funding

Mechanisms of Therapeutic Action in SCIR01HD059895 · NICHD · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI MIRBAGHERI, MEHDI M · 2009 to 2013
$1.5M
NICHD NIH HHS R01 HD059895NICHD NIH HHS R01HD059895
6 · The paper itself

Abstract

objectiveWe sought to determine the therapeutic effect of robotic-assisted step training (RAST) on neuromuscular abnormalities associated with spasticity by characterization of their recovery patterns in people with spinal cord injury (SCI).

methodsTwenty-three motor-incomplete SCI subjects received one-hour RAST sessions three times per week for 4 weeks, while an SCI control group received no training. Neuromuscular properties were assessed using ankle perturbations prior to and during the training, and a system-identification technique quantified stretch reflex and intrinsic stiffness magnitude and modulation with joint position. Growth-mixture modeling classified subjects based on similar intrinsic and reflex recovery patterns.

resultsAll recovery classes in the RAST group presented significant (p<0.05) reductions in intrinsic and reflex stiffness magnitude and modulation with position; the control group presented no changes over time. Subjects with larger baseline abnormalities exhibited larger reductions, and over longer training periods.

conclusionsOur findings demonstrate that RAST can effectively reduce neuromuscular abnormalities, with greater improvements for subjects with higher baseline abnormalities. SIGNIFICANCE: Our findings suggest, in addition to its primary goal of improving locomotor patterns, RAST can also reduce neuromuscular abnormalities associated with spasticity. These findings also demonstrate that these techniques can be used to characterize neuromuscular recovery patterns in response to various types of interventions.

Indexed as

Exercise TherapyReflex, StretchAdultAnkle JointFemaleHumansMaleMiddle AgedMuscle, SkeletalMuscle SpasticityRoboticsSpinal Cord InjuriesAnkleGait rehabilitationLocomotor trainingReflexSpasticitySpinal cord injury

Identifiers

PMID25449559
PMCPMC4369462
OpenAlexW2139148728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.