ArticlePhysiology & behavior2015
Physically active rats lose more weight during calorie restriction.
Article in Physiology & behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Ramadan fasting model modulates biomarkers of longevity and metabolism in male obese and non-obese rats.Scientific reports · 2024Article
- Ramadan fasting model exerts hepatoprotective, anti-obesity, and anti-hyperlipidemic effects in an experimentally-induced nonalcoholic fatty liver in rats.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024Article
- Prenatal caloric restriction adjusts the energy homeostasis and behavior in response to acute and chronic variations in food availability in adulthood.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2023Article
- Intrinsic cardiorespiratory fitness modulates clinical and molecular response to caloric restriction.Molecular metabolism · 2023Article
- Reduced contextually induced muscle thermogenesis in rats with calorie restriction and lower aerobic fitness but not monogenic obesity.Temperature (Austin, Tex.) · 2023Article
- RETRACTED: Cross-Generational Impact of Epigenetic Male Influence on Physical Activity in Rat.Biology · 2022Article
- Differential weight loss with intermittent fasting or daily calorie restriction in low- and high-fitness phenotypes.Experimental physiology · 2021Article
- Enhanced weight and fat loss from long-term intermittent fasting in obesity-prone, low-fitness rats.Physiology & behavior · 2021Article
- Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan.NPJ aging and mechanisms of disease · 2021Article
- Aerobic capacity modulates adaptive thermogenesis: Contribution of non-resting energy expenditure.Physiology & behavior · 2020Article
- Rats Selectively Bred for High Voluntary Physical Activity Behavior are Not Protected from the Deleterious Metabolic Effects of a Western Diet When Sedentary.Current developments in nutrition · 2019Article
- Spontaneous Physical Activity Defends Against Obesity.Current obesity reports · 2017Review
- Inherent aerobic capacity-dependent differences in breast carcinogenesis.Carcinogenesis · 2017Article
- Blaming the Brain for Obesity: Integration of Hedonic and Homeostatic Mechanisms.Gastroenterology · 2017Review
- Suppressed sympathetic outflow to skeletal muscle, muscle thermogenesis, and activity energy expenditure with calorie restriction.Physiological reports · 2017Article
- Physical Activity, Energy Expenditure, and Defense of Body Weight in Melanocortin 4 Receptor-Deficient Male Rats.Scientific reports · 2016Article
- Dietary Restriction Affects Neuronal Response Property and GABA Synthesis in the Primary Visual Cortex.PloS one · 2016Article
- Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats.Neuroscience · 2015Article
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Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Daily physical activity shows substantial inter-individual variation, and low physical activity is associated with obesity and weight gain. Elevated physical activity is also associated with high intrinsic aerobic capacity, which confers considerable metabolic health benefits. Rats artificially selected for high intrinsic aerobic capacity (high-capacity runners, HCR) are more physically active than their low-capacity counterparts (low-capacity runners, LCR). To test the hypothesis that physical activity counters metabolic thriftiness, we measured physical activity and weight loss during three weeks of 50% calorie restriction (CR) in the HCR and LCR rat lines. At baseline, HCR ate more and were more active than LCR; this was seen in male rats, where LCR are considerably heavier than HCR, as well as in a set of female rats where body weight did not differ between the lines, demonstrating that this effect is consistent across sex and not secondary to body weight. We show for the first time that HCR lose more weight than LCR relative to baseline. Physical activity levels declined throughout CR, and this was more pronounced in HCR than in LCR, yet some aspects of activity remained elevated in HCR relative to LCR even during CR. This is consistent with the idea that low physical activity contributes to metabolic thriftiness during food restriction, allowing LCR to defend body mass, particularly lean mass. This has implications for physical activity during diet-induced weight loss, the genetic underpinnings of individual differences in weight loss during a diet, and the potential evolutionary opposition between metabolic thriftiness and aerobic capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.