ArticlePhysiology & behavior2015
Naproxen attenuates sensitization of depressive-like behavior and fever during maternal separation.
Article in Physiology & behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 18 citations in OpenAlex.
- Early attachment disruption differentially enhances multiple signs of microglia activation in the prefrontal cortex, hippocampus, and preoptic area of periadolescent guinea pigs.Behavioural brain research · 2027Article
- Early Attachment Disruption Increases Central Sensitivity of Depressive-Like Behavior to Stimulation by PGE-2.Developmental psychobiology · 2025Article
- Examination of the role of adrenergic receptor stimulation in the sensitization of neuroinflammatory-based depressive-like behavior in isolated Guinea pig pups.Stress (Amsterdam, Netherlands) · 2023Article
- Sensitization of depressive-like behavior is attenuated by disruption of prostaglandin synthesis days following brief early attachment-figure isolation.Developmental psychobiology · 2022Article
- Presence of mother prompts dissociation of sickness behavior, fever, and hypothalamic gene expression in lipopolysaccharide-injected guinea pig pups.Developmental psychobiology · 2020Article
- Pharmacological Prevention of Neonatal Opioid Withdrawal in a Pregnant Guinea Pig Model.Frontiers in pharmacology · 2020Article
- Central oxytocin alters cortisol and behavioral responses of guinea pig pups during isolation in a novel environment.Physiology & behavior · 2019Article
- Central neuroimmune activity and depressive-like behavior in response to repeated maternal separation and injection of LPS.Physiology & behavior · 2019Article
- Early Attachment Disruption, Inflammation, and Vulnerability for Depression in Rodent and Primate Models.Frontiers in behavioral neuroscience · 2018Article
- Early life stress and later peer distress on depressive behavior in adolescent female rats: Effects of a novel intervention on GABA and D2 receptors.Behavioural brain research · 2017Article
- A multispecies approach for understanding neuroimmune mechanisms of stress.Dialogues in clinical neuroscience · 2017Review
- Depressive-like behavior, its sensitization, social buffering, and altered cytokine responses in rhesus macaques moved from outdoor social groups to indoor housing.Social neuroscience · 2017Article
- Maternal separation increases later immobility during forced swim in guinea pig pups: evidence for sensitization of a depressive-like state.Developmental psychobiology · 2017Article
- Commentary on the special issue on the adolescent brain: Adolescence, trajectories, and the importance of prevention.Neuroscience and biobehavioral reviews · 2016Article
- A working model for the assessment of disruptions in social behavior among aged rats: The role of sex differences, social recognition, and sensorimotor processes.Experimental gerontology · 2016Article
- Stability and change: Stress responses and the shaping of behavioral phenotypes over the life span.Frontiers in zoology · 2015Review
- Neuroimmune mechanisms of stress: sex differences, developmental plasticity, and implications for pharmacotherapy of stress-related disease.Stress (Amsterdam, Netherlands) · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Early life stress can increase susceptibility for later development of depressive illness though a process thought to involve inflammatory mediators. Isolated guinea pig pups exhibit a passive, depressive-like behavioral response and fever that appear mediated by proinflammatory activity, and which sensitize with repeated separations. Treatment with an anti-inflammatory can attenuate the behavioral response during the initial separation and separation the following day. Here we used the cyclooxygenase inhibitor naproxen to examine the role of prostaglandins in mediating the depressive-like behavior and core body temperature of young guinea pigs during an initial separation, separation the next day, and separation 10 days after the first. The passive, depressive-like behavior as well as fever sensitized with repeated separation. Three days of injection with 14 mg/kg of naproxen prior to the initial separation reduced depressive-like behavior during all three separations. A 28 mg/kg dose of naproxen, however, had minimal effect on behavior. Fever during the early separations was moderated by naproxen, but only at the higher dose. These results suggest a role of prostaglandins in the behavioral and febrile response to maternal separation, and particularly in the sensitization of depressive-like behavior following repeated separation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.