ArticleDifferentiation; research in biological diversity
Comparative effects of neonatal diethylstilbestrol on external genitalia development in adult males of two mouse strains with differential estrogen sensitivity.
Article in Differentiation; research in biological diversity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Associations between macrolide antibiotics prescribing during pregnancy and adverse child outcomes in the UK: population based cohort study.BMJ (Clinical research ed.) · 2020Article
- A critical role for estrogen signaling in penis development.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Mouse hypospadias: A critical examination and definition.Differentiation; research in biological diversity · 2016Article
- Current understanding of hypospadias: relevance of animal models.Nature reviews. Urology · 2015Review
- Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development.Differentiation; research in biological diversityArticle
- Development of the human penis and clitoris.Differentiation; research in biological diversityArticle
- Immunohistochemical expression analysis of the human fetal lower urogenital tract.Differentiation; research in biological diversityArticle
- Complex epithelial remodeling underlie the fusion event in early fetal development of the human penile urethra.Differentiation; research in biological diversityArticle
- Reproductive tract biology: Of mice and men.Differentiation; research in biological diversityReview
- Development of the human prepuce and its innervation.Differentiation; research in biological diversityArticle
- Androgen and estrogen receptor expression in the developing human penis and clitoris.Differentiation; research in biological diversityArticle
- Diethylstilbestrol-induced mouse hypospadias: "window of susceptibility".Differentiation; research in biological diversityReview
- Estrogens and development of the mouse and human external genitalia.Differentiation; research in biological diversityReview
- Ontogeny of estrogen receptors in human male and female fetal reproductive tracts.Differentiation; research in biological diversityReview
- Anatomy of the mouse penis and internal prepuce.Differentiation; research in biological diversityReview
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
The effect of neonatal exposure to diethylstilbestrol (DES), a potent synthetic estrogen, was examined to evaluate whether the CD-1 (estrogen insensitive, outbred) and C57 (estrogen sensitive, inbred) mouse strains differ in their response to estrogen disruption of male ExG differentiation. CD-1 and C57BL/6 litters were injected with sesame oil or DES (200 ng/g/5 μl in sesame oil vehicle) every other day from birth to day 10. Animals were sacrificed at the following time points: birth, 5, 10 and 60 days postnatal. Neonatally DES-treated mice from both strains had many ExG abnormalities that included the following: (a) severe truncation of the prepuce and glans penis, (b) an abnormal urethral meatus, (c) ventral tethering of the penis, (d) reduced os penis length and glans width, (e) impaired differentiation of cartilage, (f) absence of urethral flaps, and (g) impaired differentiation of erectile bodies. Adverse effects of DES correlated with the expression of estrogen receptors within the affected tissues. While the effects of DES were similar in the more estrogen-sensitive C57BL/6 mice versus the less estrogen-sensitive CD-1 mice, the severity of DES effects was consistently greater in C57BL/6 mice. We suggest that many of the effects of DES, including the induction of hypospadias, are due to impaired growth and tissue fusion events during development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.