ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2014
Identification of a novel intertypic recombinant species D human adenovirus in a pediatric stem cell transplant recipient.
Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Identification and characterization of a novel human adenovirus type HAdV-D116.Frontiers in microbiology · 2025Article
- Isolation of a novel intertypic recombinant human mastadenovirus B2 from two unrelated bone marrow transplant recipients.New microbes and new infections · 2020Article
- Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D.FEBS letters · 2019Review
- Intestinal HAdV Infection: Tissue Specificity, Persistence, and Implications for Antiviral Therapy.Viruses · 2019Review
- Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens.Emerging microbes & infections · 2018Article
- A multigene typing system for human adenoviruses reveals a new genotype in a collection of Swedish clinical isolates.PloS one · 2018Article
- Adenovirus and "Culture-Negative Sepsis" in a Preterm Neonate.AJP reports · 2016Article
- Adenovirus: Epidemiology, Global Spread of Novel Serotypes, and Advances in Treatment and Prevention.Seminars in respiratory and critical care medicine · 2016Review
- Pre-Transplant Screening for Latent Adenovirus in Donors and Recipients.The open microbiology journal · 2016Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundHuman adenoviruses (HAdV) are known opportunistic pathogens in hematopoietic stem cell transplant (SCT) recipients. The detection of HAdV infection in children after SCT has been implicated as a determinant of poor outcome but specific associations between HAdV species or individual HAdV types and disease are poorly understood.
objectivesCharacterization of a HAdV-D strain isolated from multiple clinical specimens of an 11-year-old female recipient of a matched unrelated donor peripheral SCT for T-cell lymphoma and case report. STUDY
designArchived HAdV PCR-positive plasma, urine, and stool specimens were processed for virus isolation and detailed molecular typing. Complete genomic sequencing was carried out on 2 isolates.
resultsThe patient tested positive for HAdV DNA by real-time PCR of a stool specimen at 44 days after initiation of a SCT conditioning regimen. In the subsequent 3 months, HAdV was detected in plasma, urine and stool specimens in association with symptoms of gastroenteritis and hemorrhagic cystitis. A novel HAdV-D with a HAdV20-like hexon gene was isolated from both urine and stool specimens. All isolates yielded identical restriction profiles with endonucleases BamHI, BglII, BstEII, HindIII, PstI and SmaI. Analysis of 2 complete genomic sequences further identified the virus as a novel intertypic recombinant HAdV-D (P20/H20/F42) closely related to HAdV42.
conclusionsThis case highlights the identification of a previously unknown HAdV-D from an immunocompromised host. In this patient, the course of adenovirus infection is compatible with reactivation of a latent virus or a primary opportunistic infection. Adenoviremia in this patient resolved without definitive adenovirus-directed antiviral therapy.
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