ArticleVision research2015
Correlation of vision loss with tactile-evoked V1 responses in retinitis pigmentosa.
Article in Vision research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- Did you see the sound? A Bayesian assessment on cross-modal perception in low vision.Journal of vision · 2026Article
- Ultra-High-Field MRI Morphometry of the Lateral Geniculate Nucleus in Patients with Advanced Visual Loss Due to Late-Stage Retinitis Pigmentosa.Brain sciences · 2026Article
- Did you see the sound? A Bayesian Perspective on Crossmodal Perception in Low Vision.bioRxiv : the preprint server for biology · 2025Article
- Adaptive changes in the visual cortex after photoreceptor degeneration in retinitis pigmentosa.Histology and histopathology · 2025Review
- Visual cortical thickness increases with prolonged artificial vision restoration.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Progressive Retinal Degeneration Increases Cortical Response Latency of Light Stimulation but Not of Electric Stimulation.Translational vision science & technology · 2022Article
- The detrimental effects of progression of retinal degeneration in the visual cortex.Frontiers in cellular neuroscience · 2022Review
- Gaze direction influences grasping actions towards unseen, haptically explored, objects.Scientific reports · 2020Article
- Residual Visual Responses in Patients With Retinitis Pigmentosa Revealed by Functional Magnetic Resonance Imaging.Translational vision science & technology · 2019Article
- Visual Cortical Plasticity in Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2019Article
- Now is the Critical Time for Engineered Neuroplasticity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Reorganization of early visual cortex functional connectivity following selective peripheral and central visual loss.Scientific reports · 2017Article
- Postretinal Structure and Function in Severe Congenital Photoreceptor Blindness Caused by Mutations in the GUCY2D Gene.Investigative ophthalmology & visual science · 2017Article
- Low Vision and Plasticity: Implications for Rehabilitation.Annual review of vision science · 2016Review
- Article
- Patterns of Individual Variation in Visual Pathway Structure and Function in the Sighted and Blind.PloS one · 2016Article
- Feasibility of Structural and Functional MRI Acquisition with Unpowered Implants in Argus II Retinal Prosthesis Patients: A Case Study.Translational vision science & technology · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neuroimaging studies have shown that the visual cortex of visually impaired humans is active during tactile tasks. We sought to determine if this cross-modal activation in the primary visual cortex is correlated with vision loss in individuals with retinitis pigmentosa (RP), an inherited degenerative photoreceptor disease that progressively diminishes vision later in life. RP and sighted subjects completed three tactile tasks: a symmetry discrimination task, a Braille-dot counting task, and a sandpaper roughness discrimination task. We measured tactile-evoked blood oxygenation level dependent (BOLD) responses using functional magnetic resonance imaging (fMRI). For each subject, we quantified the cortical extent of the tactile-evoked response by the proportion of modulated voxels within the primary visual cortex (V1) and its strength by the mean absolute modulation amplitude of the modulated voxels. We characterized vision loss in terms of visual acuity and the areal proportion of V1 that corresponds to the preserved visual field. Visual acuity and proportion of the preserved visual field both had a highly significant effect on the cortical extent of the V1 BOLD response to tactile stimulation, while visual acuity also had a significant effect on the strength of the V1 response. These effects of vision loss on cross-modal responses were reliable despite high inter-subject variability. Controlling for task-evoked responses in the primary somatosensory cortex (S1) across subjects further strengthened the effects of vision loss on cross-model responses in V1. We propose that such cross-modal responses in V1 and other visual areas may be used as a cortically localized biomarker to account for individual differences in visual performance following sight recovery treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.