ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2015
Oscillators and Oscillations in the Basal Ganglia.
Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Review
- From lobotomy to connectomics: a critical review of contemporary psychosurgery.Frontiers in psychiatry · 2026Review
- Emergence of structures in neuronal network activities.Scientific reports · 2025Article
- The Constrained Disorder Principle Accounts for the Variability That Characterizes Breathing: A Method for Treating Chronic Respiratory Diseases and Improving Mechanical Ventilation.Advances in respiratory medicine · 2023Review
- Article
- Altered functional connectivity associated with striatal dopamine depletion in Parkinson's disease.Cerebral cortex communications · 2023Article
- Weakly correlated activity of pallidal neurons in behaving monkeys.The European journal of neuroscience · 2021Article
- Modeling the pathophysiology of Parkinson's disease in patient-specific neurons.Experimental biology and medicine (Maywood, N.J.) · 2021Review
- Parkinson's disease uncovers an underlying sensitivity of subthalamic nucleus neurons to beta-frequency cortical input in vivo.Neurobiology of disease · 2020Article
- Broadband Entrainment of Striatal Low-Threshold Spike Interneurons.Frontiers in neural circuits · 2020Article
- Beyond Emotions: Oscillations of the Amygdala and Their Implications for Electrical Neuromodulation.Frontiers in neuroscience · 2019Review
- Effect of Phase Response Curve Shape and Synaptic Driving Force on Synchronization of Coupled Neuronal Oscillators.Neural computation · 2017Article
- Stochastic slowly adapting ionic currents may provide a decorrelation mechanism for neural oscillators by causing wander in the intrinsic period.Journal of neurophysiology · 2016Article
- Phasic Burst Stimulation: A Closed-Loop Approach to Tuning Deep Brain Stimulation Parameters for Parkinson's Disease.PLoS computational biology · 2016Article
- Unitary synaptic connections among substantia nigra pars reticulata neurons.Journal of neurophysiology · 2016Article
- Striatal Dopaminergic Innervation Regulates Subthalamic Beta-Oscillations and Cortical-Subcortical Coupling during Movements: Preliminary Evidence in Subjects with Parkinson's Disease.Frontiers in human neuroscience · 2016Article
- Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo.Brain stimulationArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
What is the meaning of an action potential? There must be different answers for neurons that fire spontaneously, even in the absence of synaptic input, and those driven to fire from a resting membrane potential. In spontaneously firing neurons, the occurrence of the next action potential is guaranteed; only variations in its timing can carry the message. In the basal ganglia, the globus pallidus, the substantia nigra, and the subthalamic nucleus consist of neurons firing spontaneously. They each receive thousands of synaptic inputs, but these are not required to maintain their background firing. Instead, synaptic interactions among basal ganglia nuclei comprise a system of coupled oscillators that produces a complex resting pattern of activity. Normally, this pattern is highly irregular and uncorrelated, so that the firing of each cell is statistically independent of the others. This maximizes the potential information that may be transmitted by the basal ganglia to its target structures. In Parkinson's disease, the resting pattern of activity is dominated by a slow oscillation shared by nearly all of the neurons. Treatment with deep brain stimulation may gain its therapeutic value by disrupting this shared pathological oscillation, and restoring independent action by each neuron in the network.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.