ArticleAmerican journal of ophthalmology2015
Retinal detachment associated with AIDS-related cytomegalovirus retinitis: risk factors in a resource-limited setting.
Article in American journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06250881 (Analysis of Ocular Complications of AIDS Patients in Ophthalmic Consultation), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Analysis of Ocular Complications of AIDS Patients in Ophthalmic Consultation
Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Cytomegalovirus Retinitis Across the Immunosuppression Spectrum: A Contemporary Framework for Risk Stratification, Diagnosis, and Vision-Preserving Therapy.Journal of clinical medicine · 2026Review
- Cytomegalovirus Retinitis in Newly Diagnosed Advanced HIV Infection: A Three-Case Series Emphasizing Multidisciplinary Infection Screening.Infectious disease reports · 2026Article
- Argon laser demarcation of AIDS-related cytomegalovirus retinitis in resource-limited setting.International ophthalmology · 2026Observational
- Retinal detachment and mortality in patients with cytomegalovirus retinitis: A multicenter study in taiwan.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Ocular Manifestations of Human Immunodeficiency Virus Infection in the Combination Antiretroviral Therapy Era.Pathogens (Basel, Switzerland) · 2023Article
- Socioeconomic disadvantage and impact on visual outcomes in patients with viral retinitis and retinal detachment.Journal of ophthalmic inflammation and infection · 2022Article
- Cytomegalovirus retinitis in the highly active anti-retroviral therapy era.Annals of eye science · 2022Article
- Do we need separate screening strategies for cytomegalovirus retinitis in different underlying immunosuppressed states? A retrospective study from Western India.Indian journal of ophthalmology · 2021Observational
- Ophthalmologic Disease in HIV Infection: Recent Changes in Pathophysiology and Treatment.Current infectious disease reports · 2017Review
- Cytomegalovirus retinitis and HIV: Case reviews from KwaZulu-Natal Province, South Africa.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2017Article
- Article
- A role for 3-O-sulfated heparan sulfate in promoting human cytomegalovirus infection in human iris cells.Journal of virology · 2015Article
- Long-Term Follow-up of Patients With Cytomegalovirus Retinitis Treated With a Ganciclovir Implant.Journal of vitreoretinal diseasesArticle
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeTo determine risk factors predictive of retinal detachment in patients with cytomegalovirus (CMV) retinitis in a setting with limited access to ophthalmic care.
designCase-control study.
methodsSixty-four patients with CMV retinitis and retinal detachment were identified from the Ocular Infectious Diseases and Retina Clinics at Chiang Mai University. Three control patients with CMV retinitis but no retinal detachment were selected for each case, matched by calendar date. The medical records of each patient were reviewed, with patient-level and eye-level features recorded for the clinic visit used to match cases and controls, and also for the initial clinic visit at which CMV retinitis was diagnosed. Risk factors for retinal detachment were assessed separately for each of these time points using multivariate conditional logistic regression models that included 1 eye from each patient.
resultsPatients with a retinal detachment were more likely than controls to have low visual acuity (odds ratio [OR], 1.24 per line of worse vision on the logMAR scale; 95% confidence interval [CI], 1.16-1.33) and bilateral disease (OR, 2.12; 95% CI, 0.92-4.90). Features present at the time of the initial diagnosis of CMV retinitis that predicted subsequent retinal detachment included bilateral disease (OR, 2.68; 95% CI, 1.18-6.08) and lesion size (OR, 2.64 per 10% increase in lesion size; 95% CI, 1.41-4.94).
conclusionBilateral CMV retinitis and larger lesion sizes, each of which is a marker of advanced disease, were associated with subsequent retinal detachment. Earlier detection and treatment may reduce the likelihood that patients with CMV retinitis develop a retinal detachment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.