Evidence map›Paper›PMID 25448722›Full record

ArticleColloids and surfaces. B, Biointerfaces2014

Proteins, platelets, and blood coagulation at biomaterial interfaces.

Li-Chong Xu, James W Bauer, Christopher A Siedlecki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Colloids and surfaces. B, Biointerfaces, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed.

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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Li-Chong XuDepartment of Surgery, Biomedical Engineering Institute, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
James W BauerDepartment of Bioengineering, Biomedical Engineering Institute, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Christopher A SiedleckiDepartment of Surgery, Biomedical Engineering Institute, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States; Department of Bioengineering, Biomedical Engineering Institute, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States. Electronic address: csiedlecki@psu.edu.

Funding

SURFACE ENGINEERING IN CONTACT ACTIVATION OF COAGULATIONR01HL069965 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SIEDLECKI, CHRISTOPHER A · 2002 to 2014
$4.1M
NHLBI NIH HHS R01 HL069965NHLBI NIH HHS R01 HL69965
6 · The paper itself

Abstract

Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant controversy and question in the field regarding the role that surfaces play in this process. This manuscript addresses this topic area and reports on state of the art in the field. Particular emphasis is placed on the subject of surface engineering and surface measurements that allow for control and observation of surface-mediated biological responses in blood and test solutions. Appropriate use of surface texturing and chemical patterning methodologies allow for reduction of both blood coagulation and platelet adhesion, and new methods of surface interrogation at high resolution allow for measurement of the relevant biological factors.

Indexed as

Biocompatible MaterialsBlood CoagulationBlood PlateletsFibrinogenHumansProteinsSurface PropertiesBiocompatible MaterialsFibrinogenProteinsBiological responseBiomaterialsBlood compatibilityCoagulationSurfacesThrombosis

Identifiers

PMID25448722
PMCPMC5001692

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.