ReviewMetabolic engineering2015
Review of methods to probe single cell metabolism and bioenergetics.
Review in Metabolic engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- A Reaction-Diffusion Frame for Accessing Metabolic OAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Label-Free Cancer Detection Methods Based on Biophysical Cell Phenotypes.Bioengineering (Basel, Switzerland) · 2025Review
- Engineering of L-threonine and L-proline biosensors by directed evolution of transcriptional regulator SerR and application for high-throughput screening.Bioresources and bioprocessing · 2025Article
- Shared metabolic shifts in endothelial cells in stroke and Alzheimer's disease revealed by integrated analysis.Scientific data · 2023Article
- Microbial metabolites in the marine carbon cycle.Nature microbiology · 2022Review
- New insights into phenotypic heterogeneity for the distinct lipid accumulation of Schizochytrium sp. H016.Biotechnology for biofuels and bioproducts · 2022Article
- Microfluidics for long-term single-cell time-lapse microscopy: Advances and applications.Frontiers in bioengineering and biotechnology · 2022Review
- Human metabolite detection by surface-enhanced Raman spectroscopy.Materials today. Bio · 2022Article
- Metabolic therapy and bioenergetic analysis: The missing piece of the puzzle.Molecular metabolism · 2021Review
- A graph neural network model to estimate cell-wise metabolic flux using single-cell RNA-seq data.Genome research · 2021Article
- Bacterial metabolic heterogeneity: origins and applications in engineering and infectious disease.Current opinion in biotechnology · 2020Review
- Spatiotemporal monitoring of intracellular metabolic dynamics by resonance Raman microscopy with isotope labeling.RSC advances · 2020Article
- Next-generation physiology approaches to study microbiome function at single cell level.Nature reviews. Microbiology · 2020Review
- Towards a widespread adoption of metabolic modeling tools in biopharmaceutical industry: a process systems biology engineering perspective.NPJ systems biology and applications · 2020Review
- A digital microfluidic system with 3D microstructures for single-cell culture.Microsystems & nanoengineering · 2020Article
- Novel computational model of gastrula morphogenesis to identify spatial discriminator genes by self-organizing map (SOM) clustering.Scientific reports · 2019Article
- Quantification of Drug Molecules in Live Single Cells Using the Single-Probe Mass Spectrometry Technique.Analytical chemistry · 2019Article
- Design of a multi-sensor platform for integrating extracellular acidification rate with multi-metabolite flux measurement for small biological samples.Biosensors & bioelectronics · 2019Article
- Self-Folding Hybrid Graphene Skin for 3D Biosensing.Nano letters · 2019Article
- Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging.Nature communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Single cell investigations have enabled unexpected discoveries, such as the existence of biological noise and phenotypic switching in infection, metabolism and treatment. Herein, we review methods that enable such single cell investigations specific to metabolism and bioenergetics. Firstly, we discuss how to isolate and immobilize individuals from a cell suspension, including both permanent and reversible approaches. We also highlight specific advances in microbiology for its implications in metabolic engineering. Methods for probing single cell physiology and metabolism are subsequently reviewed. The primary focus therein is on dynamic and high-content profiling strategies based on label-free and fluorescence microspectroscopy and microscopy. Non-dynamic approaches, such as mass spectrometry and nuclear magnetic resonance, are also briefly discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.