ArticleActa biomaterialia2015
In vivo performance of novel soybean/gelatin-based bioactive and injectable hydroxyapatite foams.
Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 45 citations in OpenAlex.
- Development of pea protein-derived 3D foam scaffolds cross-linked with heat and tannic acid for cellular agriculture applications.Current research in food science · 2025Article
- Degradation and Bone-Contact Biocompatibility of Two Drillable Magnesium Phosphate Bone Cements in an In Vivo Rabbit Bone Defect Model.Materials (Basel, Switzerland) · 2023Article
- Sudoku of porous, injectable calcium phosphate cements - Path to osteoinductivity.Bioactive materials · 2022Review
- A plant-mediated synthesis of nanostructured hydroxyapatite for biomedical applications: a review.RSC advances · 2020Review
- Repositioning Natural Antioxidants for Therapeutic Applications in Tissue Engineering.Bioengineering (Basel, Switzerland) · 2020Review
- Natural hydrogels R&D process: technical and regulatory aspects for industrial implementation.Journal of materials science. Materials in medicine · 2020Review
- Advancing fabrication and properties of three-dimensional graphene-alginate scaffolds for application in neural tissue engineering.RSC advances · 2019Article
- Flow Behavior Prior to Crosslinking: The Need for Precursor Rheology for Placement of Hydrogels in Medical Applications and for 3D Bioprinting.Progress in polymer science · 2019Article
- The Effect of the Thermosensitive Biodegradable PLGA⁻PEG⁻PLGA Copolymer on the Rheological, Structural and Mechanical Properties of Thixotropic Self-Hardening Tricalcium Phosphate Cement.International journal of molecular sciences · 2019Article
- Bioceramics and bone healing.EFORT open reviews · 2018Article
- In Vivo Osteogenic Potential of Biomimetic Hydroxyapatite/Collagen Microspheres: Comparison with Injectable Cement Pastes.PloS one · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major limitations of calcium phosphate cements (CPCs) are their relatively slow degradation rate and the lack of macropores allowing the ingrowth of bone tissue. The development of self-setting cement foams has been proposed as a suitable strategy to overcome these limitations. In previous work we developed a gelatine-based hydroxyapatite foam (G-foam), which exhibited good injectability and cohesion, interconnected porosity and good biocompatibility in vitro. In the present study we evaluated the in vivo performance of the G-foam. Furthermore, we investigated whether enrichment of the foam with soybean extract (SG-foam) increased its bioactivity. G-foam, SG-foam and non-foamed CPC were implanted in a critical-size bone defect in the distal femoral condyle of New Zealand white rabbits. Bone formation and degradation of the materials were investigated after 4, 12 and 20weeks using histological and biomechanical methods. The foams maintained their macroporosity after injection and setting in vivo. Compared to non-foamed CPC, cellular degradation of the foams was considerably increased and accompanied by new bone formation. The additional functionalization with soybean extract in the SG-foam slightly reduced the degradation rate and positively influenced bone formation in the defect. Furthermore, both foams exhibited excellent biocompatibility, implying that these novel materials may be promising for clinical application in non-loaded bone defects.
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