ArticleMedical science monitor : international medical journal of experimental and clinical research2014
Opening tight junctions may be key to opening the blood-prostate barrier.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- The Blood-prostate Barrier: An Obstacle to Drug Delivery into the Prostate.Current drug delivery · 2025Review
- Multi-omic diagnostics of prostate cancer in the presence of benign prostatic hyperplasia.Heliyon · 2023Article
- Article
- The Correlation Between Platelet Count and Survival in Prostate Cancer.Research and reports in urology · 2022Article
- The utility of cfDNA in TGCT patient management: a systematic review.Therapeutic advances in medical oncology · 2022Review
- IL-1β-primed mesenchymal stromal cells exert enhanced therapeutic effects to alleviate Chronic Prostatitis/Chronic Pelvic Pain Syndrome through systemic immunity.Stem cell research & therapy · 2021Article
- Dihydroartemisinin Promoted Bone Marrow Mesenchymal Stem Cell Homing and Suppressed Inflammation and Oxidative Stress against Prostate Injury in Chronic Bacterial Prostatitis Mice Model.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Aminoglycoside antibiotics for NIH category II chronic bacterial prostatitis: A single-cohort study with one-year follow-up.Experimental and therapeutic medicine · 2016Article
- Microbubble-mediated ultrasound promotes accumulation of bone marrow mesenchymal stem cell to the prostate for treating chronic bacterial prostatitis in rats.Scientific reports · 2016Article
- The Roles of Tight Junctions and Claudin-1 in the Microbubble-Mediated Ultrasound-Induced Enhancement of Drug Concentrations in Rat Prostate.The Journal of membrane biology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The blood-prostate barrier could be the major factor that preventing delivery of drugs to prostate tissue and leads to the failure of treatment. Studies indicate that ultrasonic sonoporation can break the blood-prostate barrier and increase the concentration of drugs, but the mechanism is still unclear. Tight junctions exist widely in the endothelial and epithelial cells of mammalians, and form the biological barrier, along with other factors. Through studies on the mechanism of ultrasound microbubbles opening the blood-brain barrier, researchers found that the main mechanism is to change the expression level of TJs proteins. Since there might be some similarities between the blood-brain barrier and the blood-prostate barrier, changing the expression level of TJs proteins may also be the main mechanism by which ultrasound microbubbles opens the blood-prostate barrier, which is worth further study.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.