ArticleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2015
Aversive startle potentiation and fear pathology: Mediating role of threat sensitivity and moderating impact of depression.
Article in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Intraindividual Variability Matters for the Correspondence Between Subjective Arousal, Valence, and Physiological Responses.Psychophysiology · 2026Article
- Threats That Arise From Within: Changes in Error Processing and the Prospective Prediction of Everyday Avoidance.Biological psychiatry global open science · 2025Article
- Evaluating the sensitivity to threat and affiliative reward (STAR) model in relation to the development of conduct problems and callous-unemotional traits across early adolescence.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
- Anhedonia is associated with overgeneralization of conditioned fear during late adolescence and early adulthood.Journal of anxiety disorders · 2024Article
- Trait boldness and emotion regulation: An event-related potential investigation.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Article
- Linking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience.Clinical psychology review · 2021Review
- Pupil Response to Affective Stimuli: a Biomarker of Early Conduct Problems in Young Children.Journal of abnormal child psychology · 2020Article
- Toward a multimodal measurement model for the neurobehavioral trait of affiliative capacity.Personality neuroscience · 2020Article
- Integrating sleep, neuroimaging, and computational approaches for precision psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Incorporating neurophysiological measures into clinical assessments: Fundamental challenges and a strategy for addressing them.Psychological assessment · 2019Review
- Interrelations Among Biologically Relevant Personality Traits, Emotion Regulation Strategies, and Clinical Symptoms.Journal of psychopathology and behavioral assessment · 2019Article
- Psychophysiological Markers of Fear and Anxiety.Current psychiatry reports · 2019Review
- Article
- Evidence of a prominent genetic basis for associations between psychoneurometric traits and common mental disorders.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Methodological issues in the use of individual brain measures to index trait liabilities: The example of noise-probe P3.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Six Years of Research on the National Institute of Mental Health's Research Domain Criteria (RDoC) Initiative: A Systematic Review.Frontiers in cellular neuroscience · 2017Review
- Psychoneurometric operationalization of threat sensitivity: Relations with clinical symptom and physiological response criteria.Psychophysiology · 2016Article
- A Chimpanzee (Clinical psychological science : a journal of the Association for Psychological Science · 2016Article
- Empirically based comparisons of the reliability and validity of common quantification approaches for eyeblink startle potentiation in humans.Psychophysiology · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Enhanced startle reactivity during exposure to unpleasant cues (aversive startle potentiation; ASP) appears in the RDoC matrix as a physiological index of acute threat response. Increased ASP has been linked to focal fear disorders and to scale measures of dispositional fearfulness (i.e., threat sensitivity; THT+). However, some studies have reported reduced ASP for fear pathology accompanied by major depressive disorder (MDD) or pervasive distress. The current study evaluated whether (a) THT+ as indexed by reported dispositional fearfulness mediates the relationship between fear disorders (when unaccompanied by depression) and ASP, and (b) depression moderates relations of THT+ and fear disorders with ASP. Fear disorder participants without MDD showed enhanced ASP whereas those with MDD (or other distress conditions) showed evidence of reduced ASP. Continuous THT+ scores also predicted ASP, and this association: (a) was likewise moderated by depression/distress, and (b) accounted for the relationship between ASP and fear pathology without MDD. These findings point to a role for the RDoC construct of acute threat, operationalized dispositionally, in enhanced ASP shown by individuals with fear pathology unaccompanied by distress pathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.